PSI-6206

Modify Date: 2024-01-02 15:17:12

PSI-6206 structure	Common Name	PSI-6206
	CAS Number	863329-66-2	Molecular Weight	260.219
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₀H₁₃FN₂O₅	Melting Point	237-238℃
	MSDS	N/A	Flash Point	N/A

Use of PSI-6206

PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.

Name	(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine
Synonym	More Synonyms

Description	PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
Target	EC90：>100 μM (HCV replicon)[1]
In Vitro	PSI-6206 (RO2433) is tested for anti-HCV activity in both a cell-based quantitative real-time RT-PCR assay and surrogate bovine viral diarrhea virus (BVDV) assays. PSI-6206 demonstrates no activity or cytoxicity in any assay[1]. The formation of the 5′-triphosphate (TP) of PSI-6130 (PSI-6130-TP) and RO2433 (RO2433-TP) increases with time and reached steady state levels at 48 h. RO2433-TP also inhibits RNA synthesis by the native HCV replicase isolated from HCV replicon cells and the recombinant HCV polymerase NS5B[2]. PSI-6206 (RO2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase[3].
References	[1]. Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48(17):5504-8. [2]. Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282(41):29 [3]. Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24.

Density	1.6±0.1 g/cm3
Melting Point	237-238℃
Molecular Formula	C₁₀H₁₃FN₂O₅
Molecular Weight	260.219
Exact Mass	260.080841
PSA	104.55000
LogP	-0.77
Index of Refraction	1.596

Hazard Codes	Xi
HS Code	2934999090

(2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate structure

(2'R)-N-Benzoyl...

CAS#:817204-32-3

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PSI-6206 Structure

PSI-6206

CAS#:863329-66-2

Literature: Journal of Medicinal Chemistry, , vol. 48, # 17 p. 5504 - 5508

Precursor 1
CAS#:817204-32-3 (2'R)-N-Benzoyl...
DownStream 2
CAS#:1064684-44-1 5'-O-(isopropyl... CAS#:1190307-88-0 Sofosbuvir

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2'-Deoxy-2'-fluoro-2'-methyluridine

PSI-6206

Uridine, 2'-deoxy-2'-fluoro-2'-methyl-

URI002

Ro-2433

2'-deoxy-2'-fluoro-2'-C-methyl-uridine

PSI6206

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PSI-6206
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: PSI-6206
Price: ￥138.0/1g ￥478.0/5g
Purity: 98.0%
Delivery: 2 Day
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Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: PSI6206
Price: $200.0/100mg $400.0/250mg $800.0/1g
Purity: 98.0%
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Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: PSI6206
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-((2R,3R,4R,5R)-3-FLUORO-4-HYDROXY-5-(HYDROXYMETHYL)-3-METHYLTETRAHYDROFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-uridine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: ￥78/1g

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