Polymyxin B nonapeptide

Modify Date: 2024-01-06 07:43:29

Polymyxin B nonapeptide structure	Common Name	Polymyxin B nonapeptide
	CAS Number	86408-36-8	Molecular Weight	963.13500
	Density	1.32g/cm3	Boiling Point	1456.2ºC at 760 mmHg
	Molecular Formula	C₄₃H₇₄N₁₄O₁₁	Melting Point	N/A
	MSDS	USA	Flash Point	834.5ºC

Use of Polymyxin B nonapeptide

Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue[1]. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[2].

Name	(2S,3R)-2-amino-N-[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]-3-hydroxybutanamide
Synonym	More Synonyms

Description	Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue[1]. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)[1].
References	[1]. Tsubery H, et al. Structure-function studies of polymyxin B nonapeptide: implications to sensitization of gram-negative bacteria. J Med Chem. 2000 Aug 10;43(16):3085-92. [2]. Ofek I, et al. Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice. Antimicrob Agents Chemother. 1994 Feb;38(2):374-7.

Density	1.32g/cm3
Boiling Point	1456.2ºC at 760 mmHg
Molecular Formula	C₄₃H₇₄N₁₄O₁₁
Molecular Weight	963.13500
Flash Point	834.5ºC
Exact Mass	962.56600
PSA	463.87000
LogP	0.27100
Index of Refraction	1.607
Storage condition	2-8℃