TP0427736 HCl

Modify Date: 2024-01-16 18:16:04

TP0427736 HCl Structure
TP0427736 HCl structure
Common Name TP0427736 HCl
CAS Number 864374-00-5 Molecular Weight 298.39
Density 1.4±0.1 g/cm3 Boiling Point 634.7±65.0 °C at 760 mmHg
Molecular Formula C14H10N4S2 Melting Point N/A
MSDS N/A Flash Point 333.8±24.7 °C

 Use of TP0427736 HCl


TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells[1].

 Names

Name TP0427736
Synonym More Synonyms

 TP0427736 HCl Biological Activity

Description TP0427736 is a selective inhibitor of ALK5 with an IC50 of 2.72 nM. TP0427736 inhibits Smad2/3 phosphorylation in A549 cells. TP0427736 decreases the growth inhibition of human outer root sheath cells[1].
Related Catalog
References

[1]. Naruse T, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-βinduced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 Jun;69(3):485-491.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 634.7±65.0 °C at 760 mmHg
Molecular Formula C14H10N4S2
Molecular Weight 298.39
Flash Point 333.8±24.7 °C
Exact Mass 298.034698
LogP 3.37
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.740
Storage condition Store at -20°C
Water Solubility DMSO :≥50mg/mL

 Safety Information

Hazard Codes N

 Synonyms

6-[4-(4-Methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole
Benzothiazole, 6-[4-(4-methyl-2-thiazolyl)-1H-imidazol-5-yl]-
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