4-oxo-4-HPR

Modify Date: 2024-06-09 23:37:57

4-oxo-4-HPR Structure
4-oxo-4-HPR structure
Common Name 4-oxo-4-HPR
CAS Number 865536-65-8 Molecular Weight 405.53
Density 1.131g/cm3 Boiling Point 641.8ºC at 760 mmHg
Molecular Formula C26H31NO3 Melting Point N/A
MSDS N/A Flash Point 341.9ºC

 Use of 4-oxo-4-HPR


4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1].

 Names

Name (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)nona-2,4,6,8-tetraenamide
Synonym More Synonyms

 4-oxo-4-HPR Biological Activity

Description 4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9[1].
Related Catalog
References

[1]. VillaniMG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite,induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitiveand fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.  

[2]. Villani MG, et al. 4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines. Cancer Res. 2006 Mar 15;66(6):3238-47.  

 Chemical & Physical Properties

Density 1.131g/cm3
Boiling Point 641.8ºC at 760 mmHg
Molecular Formula C26H31NO3
Molecular Weight 405.53
Flash Point 341.9ºC
Exact Mass 405.23000
PSA 66.40000
LogP 6.11430
Index of Refraction 1.615
Storage condition -20℃

 Synonyms

4-oxo-4-HPR
N-(4-Hydroxyphenyl)-4-oxoretinamide
4-oxo-N-(4-hydroxyphenyl)retinamide
3-Keto fenretinide
4-Oxo Fenretinide
4-Keto-4-HPR
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