Trelagliptin structure
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Common Name | Trelagliptin | ||
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CAS Number | 865759-25-7 | Molecular Weight | 357.382 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | 519.0±60.0 °C at 760 mmHg | |
Molecular Formula | C18H20FN5O2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 267.7±32.9 °C |
Use of TrelagliptinTrelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). IC50 value:Target: DPP4Two Phase II clinical studies have been completed with Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus. Phase III clinical studies with trelagliptin in Japan to evaluate its safety and efficacy in a once-weekly oral treatment regimen. Currently, all available DPP-4 inhibitors are dosed once-daily. A once-weekly treatment, such as trelagliptin, would provide patients with a convenient treatment alternative and has the potential to improve treatment compliance. |
Name | 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile |
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Synonym | More Synonyms |
Description | Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). IC50 value:Target: DPP4Two Phase II clinical studies have been completed with Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus. Phase III clinical studies with trelagliptin in Japan to evaluate its safety and efficacy in a once-weekly oral treatment regimen. Currently, all available DPP-4 inhibitors are dosed once-daily. A once-weekly treatment, such as trelagliptin, would provide patients with a convenient treatment alternative and has the potential to improve treatment compliance. |
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Related Catalog | |
References |
[1]. Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus [2]. Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 519.0±60.0 °C at 760 mmHg |
Molecular Formula | C18H20FN5O2 |
Molecular Weight | 357.382 |
Flash Point | 267.7±32.9 °C |
Exact Mass | 357.160095 |
PSA | 97.05000 |
LogP | 1.88 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.646 |
Storage condition | -20°C |
Water Solubility | Practically insoluble (0.034 g/L) (25 ºC) |
Trelagliptin (USAN) |
2-({6-[(3R)-3-Amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)-4-fluorobenzonitrile |
Trelagliptin |
UNII-Q836OWG55H |
Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro- |
SYR 472 |