Trelagliptin

Modify Date: 2024-01-02 13:57:12

Trelagliptin Structure
Trelagliptin structure
Common Name Trelagliptin
CAS Number 865759-25-7 Molecular Weight 357.382
Density 1.4±0.1 g/cm3 Boiling Point 519.0±60.0 °C at 760 mmHg
Molecular Formula C18H20FN5O2 Melting Point N/A
MSDS N/A Flash Point 267.7±32.9 °C

 Use of Trelagliptin


Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). IC50 value:Target: DPP4Two Phase II clinical studies have been completed with Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus. Phase III clinical studies with trelagliptin in Japan to evaluate its safety and efficacy in a once-weekly oral treatment regimen. Currently, all available DPP-4 inhibitors are dosed once-daily. A once-weekly treatment, such as trelagliptin, would provide patients with a convenient treatment alternative and has the potential to improve treatment compliance.

 Names

Name 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile
Synonym More Synonyms

 Trelagliptin Biological Activity

Description Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D). IC50 value:Target: DPP4Two Phase II clinical studies have been completed with Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus. Phase III clinical studies with trelagliptin in Japan to evaluate its safety and efficacy in a once-weekly oral treatment regimen. Currently, all available DPP-4 inhibitors are dosed once-daily. A once-weekly treatment, such as trelagliptin, would provide patients with a convenient treatment alternative and has the potential to improve treatment compliance.
Related Catalog
References

[1]. Efficacy of SYR-472 in Subjects With Type 2 Diabetes Mellitus

[2]. Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus

[3]. Long-term Study of SYR-472

[4]. SYR-472 Open-label Study

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 519.0±60.0 °C at 760 mmHg
Molecular Formula C18H20FN5O2
Molecular Weight 357.382
Flash Point 267.7±32.9 °C
Exact Mass 357.160095
PSA 97.05000
LogP 1.88
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.646
Storage condition -20°C
Water Solubility Practically insoluble (0.034 g/L) (25 ºC)

 Synonyms

Trelagliptin (USAN)
2-({6-[(3R)-3-Amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)-4-fluorobenzonitrile
Trelagliptin
UNII-Q836OWG55H
Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluoro-
SYR 472
Top Suppliers:I want be here




Get all suppliers and price by the below link:

Trelagliptin suppliers


Price: $55/10mM*1mLinDMSO

Reference only. check more Trelagliptin price