ABT-384

Modify Date: 2024-01-24 13:11:07

ABT-384 structure	Common Name	ABT-384
	CAS Number	868623-40-9	Molecular Weight	493.56
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₄F₃N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ABT-384

ABT-384 is a selective 11-β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor. ABT-384 blocks regeneration of active cortisol. ABT-384 exhibits high affinity against rodent, monkey, and human HSD-1 whit a Ki of 0.1-2.7 nM[1][2].

Name	ABT-384

Description	ABT-384 is a selective 11-β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor. ABT-384 blocks regeneration of active cortisol. ABT-384 exhibits high affinity against rodent, monkey, and human HSD-1 whit a Ki of 0.1-2.7 nM[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
In Vivo	ABT-384 can be used for the research of the Cushing’s syndrome, obesity, insulin resistance, hypertension, dyslipidemia, osteoporosis, glaucoma, major depressive disorder, and Alzheimer’s disease (AD) [2] .
References	[1]. [1] Katz DA, et al. Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384. Transl Psychiatry. 2013;3(8):e295. Published 2013 Aug 27. [2]. [2] Liu W, et al. Clinical Safety, Pharmacokinetics, and Pharmacodynamics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers and Elderly Adults. Clin Pharmacol Drug Dev. 2013;2(2):133-151.

Molecular Formula	C₂₅H₃₄F₃N₅O₂
Molecular Weight	493.56

ABT-384

Use of ABT-384

Names

ABT-384 Biological Activity

Chemical & Physical Properties