Neurokinin A trifluoroacetate salt

Modify Date: 2024-01-04 11:53:08

Neurokinin A trifluoroacetate salt structure	Common Name	Neurokinin A trifluoroacetate salt
	CAS Number	86933-74-6	Molecular Weight	1133.32000
	Density	1.305 g/cm3	Boiling Point	1610.7ºC at 760 mmHg
	Molecular Formula	C₅₀H₈₀N₁₄O₁₄S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	927.9ºC

Use of Neurokinin A trifluoroacetate salt

Neurokinin A acts via neurokinin 2 (NK-2) receptor.

Name	neurokinin a
Synonym	More Synonyms

Description	Neurokinin A acts via neurokinin 2 (NK-2) receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Peptides
Target	NK-2 receptor[1]
In Vitro	Neurokinin A (substance K) is a peptide neurotransmitter of the tachykinin family with potential as a major mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the NK-2 receptor believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. Neurokinin A is a member of a family of peptide neurotransmitters known as tachykinins. These peptides are associated with the central and peripheral nervous systems and display a wide tissue distribution. Tachykinins share the COOH-terminal structure Phe-X-Gly-Leu-Met-NH. The best known members of this family are Substance P and Neurokinin A or Substance K[1].
References	[1]. Gerard NP, et al. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues. J Biol Chem. 1990 Nov 25;265(33):20455-62.

Density	1.305 g/cm3
Boiling Point	1610.7ºC at 760 mmHg
Molecular Formula	C₅₀H₈₀N₁₄O₁₄S
Molecular Weight	1133.32000
Flash Point	927.9ºC
Exact Mass	1132.57000
PSA	488.77000
LogP	1.05310
Index of Refraction	1.58
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases	R20/21/22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3

Neurogenic airway inflammation induced by repeated intra-esophageal instillation of HCl in guinea pigs.

Inflammation 36(2) , 493-500, (2013)

This study was conducted to investigate if repeated intra-esophageal acid administrations may induce neurogenic inflammation in the airways and nodose ganglion in a guinea pig model. Guinea pigs were ...

Role of tachykinins and neurokinin receptor subtypes in the regulation of motility of the forestomach and abomasum in conscious sheep.

Neuropeptides 47(1) , 9-18, (2013)

The present study was planned to evaluate role of tachykinins (TKs) and neurokinin (NK) receptors in the regulation of gastric motility in sheep. We examined the effects of intravenous (i.v.) injectio...

Neuromodulation mediated by the tachykinin NK3-receptor agonist [MePhe7]-neurokinin B in the isolated perfused lung of nonsensitized nonchallenged and ovalbumin-sensitized and -challenged guinea pig.

Exp. Lung Res. 38(5) , 233-49, (2012)

The neuromodulatory action of the tachykinin NK(3)-receptor agonist [MePhe(7)]-neurokinin B ([MePhe(7)]-NKB) was evaluated on vagal stimulation-induced bronchoconstriction in nonsensitized nonchalleng...

Neurokinin A [NKA]

MFCD00167560

A-neurokinin

HKTDSFVGLM-NH2