(3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate

Modify Date: 2024-01-12 11:45:42

(3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate Structure
(3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate structure
Common Name (3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate
CAS Number 870640-64-5 Molecular Weight 349.508
Density 1.0±0.1 g/cm3 Boiling Point 426.3±35.0 °C at 760 mmHg
Molecular Formula C21H35NO3 Melting Point N/A
MSDS N/A Flash Point 211.6±25.9 °C

 Use of (3R,4S,5S)-tert-butyl 4-(benzyl(methyl)amino)-3-methoxy-5-methylheptanoate


Monomethyl auristatin E intermediate-13 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

 Names

Name 2-Methyl-2-propanyl (3R,4S,5S)-4-[benzyl(methyl)amino]-3-methoxy-5-methylheptanoate
Synonym More Synonyms

  Biological Activity

Description Monomethyl auristatin E intermediate-13 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Related Catalog
References

[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.  

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 426.3±35.0 °C at 760 mmHg
Molecular Formula C21H35NO3
Molecular Weight 349.508
Flash Point 211.6±25.9 °C
Exact Mass 349.261688
LogP 4.77
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.492

 Synonyms

Heptanoic acid, 3-methoxy-5-methyl-4-[methyl(phenylmethyl)amino]-, 1,1-dimethylethyl ester, (3R,4S,5S)-
2-Methyl-2-propanyl (3R,4S,5S)-4-[benzyl(methyl)amino]-3-methoxy-5-methylheptanoate