IMB-808
Modify Date: 2024-03-05 17:20:02
IMB-808 structure
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Common Name | IMB-808 | ||
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| CAS Number | 870768-70-0 | Molecular Weight | 380.32 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 572.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H15F3N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 300.2±30.1 °C | |
Use of IMB-808IMB-808 is a potent LXRα/β dual agonist with EC50 values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research[1]. |
| Name | IMB-808 |
|---|---|
| Synonym | More Synonyms |
| Description | IMB-808 is a potent LXRα/β dual agonist with EC50 values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research[1]. |
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| Related Catalog | |
| In Vitro | IMB-808 (0.001 μM-30 μM) 在 0.001 μM 到 30 μM 的浓度范围内显着剂量依赖性地诱导 LXRβ 激活，EC50 为 0.53 μM。在使用 GAL4-pGL4-luc 报告质粒的荧光素酶报告基因测定中，IMB-808 还可以剂量依赖性地激活 LXRα，EC50 为 0.15 μM[1]. IMB-808（0 μM-10 μM；18 小时）显着增加 RAW264.7 巨噬细胞中 ABCG1 和 ABCA1 的蛋白质和 mRNA 水平[1]。 IMB-808（0.1 μM、0.3 μM、1 μM、3 μM 或 10 μM；24 小时）剂量依赖性地促进胆固醇流向，并降低细胞系中的细胞胆固醇浓度[ 1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 572.8±50.0 °C at 760 mmHg |
| Molecular Formula | C18H15F3N2O4 |
| Molecular Weight | 380.32 |
| Flash Point | 300.2±30.1 °C |
| Exact Mass | 380.098389 |
| LogP | 2.96 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.592 |
| N-Methyl-N-(2-oxo-2-((2,3,4-trifluorophenyl)amino)ethyl)-3,4-dihydro-2H-benzo[b][1,4] dioxin-7-carboxamide |
| IMB-808 |
| N-Methyl-N-{2-oxo-2-[(2,3,4-trifluorophenyl)amino]ethyl}-2,3-dihydro-1,4-benzodioxine-6-carboxamide |
| 1,4-Benzodioxin-6-carboxamide, 2,3-dihydro-N-methyl-N-[2-oxo-2-[(2,3,4-trifluorophenyl)amino]ethyl]- |
| 2,3-Dihydro-N-methyl-N-[2-oxo-2-[(2,3,4-trifluorophenyl)amino]ethyl]-1,4-benzodioxin-6-carboxamide |