PCI-27483
Modify Date: 2024-01-06 18:16:14
PCI-27483 structure
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Common Name | PCI-27483 | ||
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| CAS Number | 871266-63-6 | Molecular Weight | 596.569 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H24N6O9S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PCI-27483PCI-27483 is a FVIIa/tissue factor inhibitor, with antitumour effects. |
| Name | L-Aspartic acid, N-[2-[5-[6-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5'-(aminosulfonyl)-2',6-dihydroxy[1,1'-biphenyl]-3-yl]acetyl] |
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| Synonym | More Synonyms |
| Description | PCI-27483 is a FVIIa/tissue factor inhibitor, with antitumour effects. |
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| Related Catalog | |
| In Vitro | PCI-27483 inhibits the TF:FVIIa-complex induced phosphorylation of ERK1/2 and subsequent induction of c-fos in BxPC3 cells, a human pancreatic adenocarcinoma line that highly expresses TF. Furthermore, PCI-27483 blocks the TF:FVIIa induced secretion of IL8 in both BxPC3 cells and MDA-MB-231 breast cancer cells[2]. |
| In Vivo | PCI-27483 shows dose-dependent inhibition of thrombus formation, fibrin accumulation and PT. PCI-27483 (4 mg/kg) shows comparable anticoagulation effects as 2 mg/kg enoxaparin[1]. PCI-27483 (0 and 90 mg/kg, s.c.) results in inhibition of tumor growth in CD1 nu/nu mice implanted with BxPC3 cells[2]. |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Molecular Formula | C26H24N6O9S |
| Molecular Weight | 596.569 |
| Exact Mass | 596.132568 |
| PSA | 291.25000 |
| LogP | -0.74 |
| Index of Refraction | 1.775 |
| L-Aspartic acid, N-[2-[5-[6-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5'-(aminosulfonyl)-2',6-dihydroxy[1,1'-biphenyl]-3-yl]acetyl]- |
| L-Aspartic acid, N-[[5-[5-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5'-(aminosulfonyl)-2',6-dihydroxy[1,1'-biphenyl]-3-yl]acetyl]- |
| (S)-2-[[2-[5-(5-Carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetyl]amino]succinic acid |
| PCI27483/PCI-27483 |
| N-{[5-(5-Carbamimidoyl-1H-benzimidazol-2-yl)-2',6-dihydroxy-5'-sulfamoyl-3-biphenylyl]acetyl}-L-aspartic acid |
| PCI-27483 |