JNJ-26489112
Modify Date: 2024-01-20 07:01:45
JNJ-26489112 structure
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Common Name | JNJ-26489112 | ||
|---|---|---|---|---|
| CAS Number | 871824-55-4 | Molecular Weight | 278.713 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 457.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C9H11ClN2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 230.7±31.5 °C | |
Use of JNJ-26489112JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures; exhibits very weak inhibition of human CA-II (IC50=35 μM); inhibits Na+, kainate, and KCNQ2 channels to varying degrees, while moderately potentiating GABA current and inhibiting N-methyl-D-aspartic acid current, its action at several targets appears to be responsible for the observed neurostabilizing effects; shows limited seizure spread and elevated seizure threshold in preclinical animal models. Epilepsy Discontinued |
| Name | JNJ-26489112 |
|---|---|
| Synonym | More Synonyms |
| Description | JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures; exhibits very weak inhibition of human CA-II (IC50=35 μM); inhibits Na+, kainate, and KCNQ2 channels to varying degrees, while moderately potentiating GABA current and inhibiting N-methyl-D-aspartic acid current, its action at several targets appears to be responsible for the observed neurostabilizing effects; shows limited seizure spread and elevated seizure threshold in preclinical animal models. Epilepsy Discontinued |
|---|---|
| References | References 1. McComsey DF, et al. J Med Chem. 2013 Nov 27;56(22):9019-30. View Related Products by Target Other Targets Epilepsy |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 457.8±55.0 °C at 760 mmHg |
| Molecular Formula | C9H11ClN2O4S |
| Molecular Weight | 278.713 |
| Flash Point | 230.7±31.5 °C |
| Exact Mass | 278.012817 |
| LogP | 1.03 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.597 |
| Sulfamide, N-[[(2S)-6-chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]- |
| N-{[(2S)-6-Chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}sulfuric diamide |
| JNJ-26489112 |
| G1TI012DLT |