871824-55-4

871824-55-4 structure

Name: JNJ-26489112
Chemical Name: JNJ-26489112
CAS Number: 871824-55-4
Molecular Formula: C₉H₁₁ClN₂O₄S
Molecular Weight: 278.713
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2020-01-11 13:32:55
Modify Date: 2024-01-20 07:01:45
JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures; exhibits very weak inhibition of human CA-II (IC50=35 μM); inhibits Na+, kainate, and KCNQ2 channels to varying degrees, while moderately potentiating GABA current and inhibiting N-methyl-D-aspartic acid current, its action at several targets appears to be responsible for the observed neurostabilizing effects; shows limited seizure spread and elevated seizure threshold in preclinical animal models. Epilepsy Discontinued

Name	JNJ-26489112
Synonyms	Sulfamide, N-[[(2S)-6-chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl]- N-{[(2S)-6-Chloro-2,3-dihydro-1,4-benzodioxin-2-yl]methyl}sulfuric diamide JNJ-26489112 G1TI012DLT

Description	JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures; exhibits very weak inhibition of human CA-II (IC50=35 μM); inhibits Na+, kainate, and KCNQ2 channels to varying degrees, while moderately potentiating GABA current and inhibiting N-methyl-D-aspartic acid current, its action at several targets appears to be responsible for the observed neurostabilizing effects; shows limited seizure spread and elevated seizure threshold in preclinical animal models. Epilepsy Discontinued
References	References 1. McComsey DF, et al. J Med Chem. 2013 Nov 27;56(22):9019-30. View Related Products by Target Other Targets Epilepsy