Dipraglurant

Modify Date: 2024-01-14 18:29:05

Dipraglurant Structure
Dipraglurant structure
Common Name Dipraglurant
CAS Number 872363-17-2 Molecular Weight 265.28500
Density N/A Boiling Point N/A
Molecular Formula C16H12FN3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Dipraglurant


Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM. IC50 Value: 0.021 μM [1]Target: mGluRDipraglurant (ADX-48621) from Addex Therapeutics showed in vivo activity in different anxiety models in rat50 and is currently in phase II for the treatment of dyskinesia in Parkinson's disease.

 Names

Name 6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine
Synonym More Synonyms

 Dipraglurant Biological Activity

Description Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM. IC50 Value: 0.021 μM [1]Target: mGluRDipraglurant (ADX-48621) from Addex Therapeutics showed in vivo activity in different anxiety models in rat50 and is currently in phase II for the treatment of dyskinesia in Parkinson's disease.
Related Catalog
References

[1]. The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12

 Chemical & Physical Properties

Molecular Formula C16H12FN3
Molecular Weight 265.28500
Exact Mass 265.10200
PSA 30.19000
LogP 2.85270

 Synonyms

Dipraglurant
CS-0690
Dipraglurant [INN]
UNII-CV8JZR21A1