Cefpodoxime Proxetil

Modify Date: 2024-01-04 19:45:00

Cefpodoxime Proxetil Structure
Cefpodoxime Proxetil structure
 Common Name Cefpodoxime Proxetil
CAS Number 87239-81-4 Molecular Weight 557.597
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C21H27N5O9S2 Melting Point 111-113°C
MSDS N/A Flash Point N/A

 Use of Cefpodoxime Proxetil


Cefpodoxime Proxetil is a first oral and broad spectrum antibiotic that belongs to the third generation of cephalosporin. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis[1].

 Names

Name cefpodoxime proxetil
Synonym More Synonyms

 Cefpodoxime Proxetil Biological Activity

Description Cefpodoxime Proxetil is a first oral and broad spectrum antibiotic that belongs to the third generation of cephalosporin. Cefpodoxime Proxetil binds to penicillin binding proteins (PBPs), which inhibits peptidoglycan synthesis, finally results in interfering bacterial cell wall biosynthesis[1].
Related Catalog
References

[1]. Iqbal S, et al. In vitro Spectroscopic studies on drug interaction of cefpodoxime proxetil and H2 receptor blockers. Pak J Pharm Sci. 2019 Mar;32(2 (Supplementary)):881-887.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Melting Point 111-113°C
Molecular Formula C21H27N5O9S2
Molecular Weight 557.597
Exact Mass 557.125000
PSA 234.51000
LogP 2.17
Index of Refraction 1.671
Storage condition -20?C Freezer

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2941905990

 Synthetic Route

1-Iodoethyl isopropyl carbonate structure

1-Iodoethyl iso...

CAS#:84089-73-6

cefpodoxime structure

cefpodoxime

CAS#:80210-62-4

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Cefpodoxime Proxetil Structure

Cefpodoxime Proxetil

CAS#:87239-81-4

Literature: WO2004/48387 A1, ; Page 7-8 ;
1-((isopropoxycarbonyl)oxy)ethyl (6R,7R)-7-((Z)-2-(2-(2-chloroacetamido)thiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate structure

1-((isopropoxyc...

CAS#:620962-96-1

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Cefpodoxime Proxetil Structure

Cefpodoxime Proxetil

CAS#:87239-81-4

Literature: Rodriguez, Juan C.; Hernandez, Ricardo; Gonzalez, Maritza; Rodriguez, Zalua; Tolon, Blanca; Velez, Herman; Valdes, Barbara; Lopez, Miguel A.; Fini, Adamo Farmaco, 2003 , vol. 58, # 5 p. 363 - 369
7-Aminocephalosporanic acid structure

7-Aminocephalos...

CAS#:957-68-6

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Cefpodoxime Proxetil Structure

Cefpodoxime Proxetil

CAS#:87239-81-4

Literature: Farmaco, , vol. 58, # 5 p. 363 - 369
cefotaxime structure

cefotaxime

CAS#:63527-52-6

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Cefpodoxime Proxetil Structure

Cefpodoxime Proxetil

CAS#:87239-81-4

Literature: Farmaco, , vol. 58, # 5 p. 363 - 369
1-Chloroethyl isopropyl carbonate structure

1-Chloroethyl i...

CAS#:98298-66-9

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Cefpodoxime Proxetil Structure

Cefpodoxime Proxetil

CAS#:87239-81-4

Literature: Farmaco, , vol. 58, # 5 p. 363 - 369
1-Iodoethyl isopropyl carbonate structure

1-Iodoethyl iso...

CAS#:84089-73-6

~%

Cefpodoxime Proxetil Structure

Cefpodoxime Proxetil

CAS#:87239-81-4

Literature: Farmaco, , vol. 58, # 5 p. 363 - 369
S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate structure

S-2-Benzothiazo...

CAS#:80756-85-0

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Cefpodoxime Proxetil Structure

Cefpodoxime Proxetil

CAS#:87239-81-4

Literature: Farmaco, , vol. 58, # 5 p. 363 - 369
7β-[2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylic acid structure

7β-[2-(2-chloro...

CAS#:82618-67-5

~%

Cefpodoxime Proxetil Structure

Cefpodoxime Proxetil

CAS#:87239-81-4

Literature: Farmaco, , vol. 58, # 5 p. 363 - 369
(6R,7R)-3-(acetyloxymethyl)-7-[[(2E)-2-[2-[(2-chloroacetyl)amino]-1,3-thiazol-4-yl]-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid structure

(6R,7R)-3-(acet...

CAS#:64486-19-7

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Cefpodoxime Proxetil Structure

Cefpodoxime Proxetil

CAS#:87239-81-4

Literature: Farmaco, , vol. 58, # 5 p. 363 - 369

 Customs

HS Code 2941905990

 Articles40

More Articles
A multicentric, open label, randomised, postmarketing efficacy study comparing multidose of lincomycin hydrochloride capsule 500 mg with multidose cefpodoxime proxetil tablet 200 mg in patients with tonsillitis, sinusitis.

J. Indian Med. Assoc. 110(8) , 580-3, (2012)

Tonsillitis causes considerable short and medium term morbidity, and can be recurrent. Sinusitis can be acute (less than 4 weeks), subacute (4-8 weeks) or chronic (8 weeks or more). To study the compa...

Ionic liquids as superior solvents for headspace gas chromatography of residual solvents with very low vapor pressure, relevant for pharmaceutical final dosage forms.

J. Chromatogr. A. 1216(32) , 6020-3, (2009)

1-n-Butyl-3-methylimidazolium dimethyl phosphate (BMIM DMP) was identified as the most suitable ionic liquid as solvent for the headspace gas chromatographic analysis of solvents with very low vapor p...

Cefpodoxime proxetil. An appraisal of its use in antibacterial cost-containment programmes, as stepdown and abbreviated therapy in respiratory tract infections.

Pharmacoeconomics 10(2) , 164-78, (1996)

Cefpodoxime proxetil is an orally administered prodrug which is converted in vivo to the third generation cephalosporin cefpodoxime. Cefpodoxime has a similar spectrum of antibacterial activity to the...

 Synonyms

R-3763
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, 1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester, (6R,7R)-
Cefodox
JP,USP
Cefpodoxime proxetil
1-isopropoxycarbonyloxyethyl (6R,7R)-7-[2-(2-aminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-(methoxymethyl)-3-cephem-4-carboxylate
Orelox
CS-807
1-({[(1-methylethyl)oxy]carbonyl}oxy)ethyl (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-[(methyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Cefpodoxime 1-(Isopropoxycarbonyloxy)ethyl ester
Podomexef
BANAN
UNII:2TB00A1Z7N
[6R-[6a,7b(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid 1-[[(1-Methylethoxy)carbonyl]oxy]ethyl Ester
MFCD00864906
1-[(Isopropoxycarbonyl)oxy]ethyl (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
1-(Isopropoxycarbonyloxy)ethyl (6R,7R)-7-[2-(2-Amino-4-thiazolyl)-(Z)-2-(methoxyimino)acetamido]-3-methoxymethyl-3-cephem-4-carboxylate
1-[(Isopropoxycarbonyl)oxy]ethyl (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
cefpodoxime 1-(isopropyloxycarbonyloxy)ethyl ester
cefprodoxime proxetil
1-{[(1-Methylethoxy)carbonyl]oxy}ethyl-(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat
Otreon
cefpodoxime-proxetil
1-{[(1-methylethoxy)carbonyl]oxy}ethyl (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-3-(methoxymethyl)-8-oxo-, 1-[[(1-methylethoxy)carbonyl]oxy]ethyl ester, (6R,7R)-
1-{[(propan-2-yloxy)carbonyl]oxy}ethyl (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Vantin
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Chemsrc provides Cefpodoxime Proxetil(CAS#:87239-81-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Cefpodoxime Proxetil are included as well.>> amp version: Cefpodoxime Proxetil

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