Propargyl-PEG4-Tos
Modify Date: 2024-01-08 07:48:08
Propargyl-PEG4-Tos structure
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Common Name | Propargyl-PEG4-Tos | ||
|---|---|---|---|---|
| CAS Number | 875770-32-4 | Molecular Weight | 386.460 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 498.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H26O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 255.0±28.7 °C | |
Use of Propargyl-PEG4-TosPropargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2]. |
| Name | 3,6,9,12-Tetraoxapentadec-14-yn-1-yl 4-methylbenzenesulfonate |
|---|---|
| Synonym | More Synonyms |
| Description | Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1][2]. |
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| Related Catalog | |
| Target |
PEGs Cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 498.1±45.0 °C at 760 mmHg |
| Molecular Formula | C18H26O7S |
| Molecular Weight | 386.460 |
| Flash Point | 255.0±28.7 °C |
| Exact Mass | 386.139923 |
| LogP | 0.78 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.507 |
| 3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 4-methylbenzenesulfonate |
| 3,6,9,12-Tetraoxapentadec-14-yn-1-yl 4-methylbenzenesulfonate |