LM985

Modify Date: 2024-01-22 18:29:14

LM985 Structure
LM985 structure
Common Name LM985
CAS Number 87626-56-0 Molecular Weight 379.44900
Density N/A Boiling Point N/A
Molecular Formula C23H25NO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LM985


LM985 is one of a series of compounds based on the flavone ring structure, with anti-tumor activities.

 Names

Name 2-(diethylamino)ethyl 2-(4-oxo-2-phenylchromen-8-yl)acetate
Synonym More Synonyms

 LM985 Biological Activity

Description LM985 is one of a series of compounds based on the flavone ring structure, with anti-tumor activities.
Related Catalog
In Vitro LM985 shows inhibitory effects against MAC 13 cells, but MAC 15A cells are less sensitive to LM985[1].
In Vivo LM985 (200 mg/kg, s.c.) shows moderate activity against MAC 13, and after repeated injection 7 days, responses are considerably enhanced[2].
References

[1]. M. C. Bibby, et al. Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid). Br J Cancer. 1987 Feb; 55(2): 159-163.

[2]. J. A. Double, et al. Pharmacokinetics and anti-tumour activity of LM985 in mice bearing transplantable adenocarcinomas of the colon. Br J Cancer. 1986 Oct; 54(4): 595-600.

 Chemical & Physical Properties

Molecular Formula C23H25NO4
Molecular Weight 379.44900
Exact Mass 379.17800
PSA 59.75000
LogP 3.88750
Storage condition 2-8℃

 Synonyms

lm 985
LM985