6-Hydroxyrubiadin

Modify Date: 2024-01-09 20:22:07

Use of 6-Hydroxyrubiadin

6-Hydroxyrubiadin, a natural anthraquinone, may be a potential therapeutic candidate for the treatment of inflammation and inflammatory diseases[1].

Name	6-Hydroxyrubiadin
Synonym	More Synonyms

Description	6-Hydroxyrubiadin, a natural anthraquinone, may be a potential therapeutic candidate for the treatment of inflammation and inflammatory diseases[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	6-hydroxyrubiadin suppresses lipopolysaccharide (LPS)-induced nuclear factor-kappa B activation as well as the phosphorylation of c-Jun N-terminal kinase in RAW 264.7 macrophages[1]. 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-a, interleukin (IL)-1b and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7cells[1].
In Vivo	6-hydroxyrubiadin can reduce the production of pro-inflammatory cytokines and ameliorate acute lung injury (ALI) in a mouse model[1].
References	[1]. Yanting Wu, et al. In vitro and in vivo inhibitory effects of 6-hydroxyrubiadin on lipopolysaccharide-induced inflammation. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):107-116.

Hazard Codes	Xi

1,3,6-Trihydroxy-2-methyl-9,10-anthraquinone

1,3,6-trihydroxy-2-methylanthracene-9,10-dione

9,10-Anthracenedione, 1,3,6-trihydroxy-2-methyl-

2-Methyl-1,3,6-trihydroxyanthraquinone

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