PhiKan 083
Modify Date: 2024-01-20 19:43:56
PhiKan 083 structure
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Common Name | PhiKan 083 | ||
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| CAS Number | 880813-36-5 | Molecular Weight | 238.33 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H18N2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PhiKan 083PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR[1], and a relative binding affinity (Kd) of 150 μM in Ln229 cells[3]. |
| Name | 1-(9-Ethyl-9H-carbazol-3-yl)-N-methylmethanamine hydrochloride (1 :1) |
|---|---|
| Synonym | More Synonyms |
| Description | PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR[1], and a relative binding affinity (Kd) of 150 μM in Ln229 cells[3]. |
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| Related Catalog | |
| Target |
Kd: 167 μM (p53-Y220C)[1], 150 μM (p53Y220C, in Ln229 cells)[3] |
| In Vitro | PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM measured by NMR[1], shows a relative binding affinity (Kd) of 150 μM for p53Y220C in Ln229 cells[3]. PhiKan083 slows down its thermal denaturation rate[2]. PhiKan 083 (125 μM) reduces the cell viability of engineered variants of Ln229 cells. PhiKan 083 (100 μM) in conbination with doxorubicin (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p535, p53Y220C, p53G245S, p53R282W)[3]. |
| References |
| Molecular Formula | C16H18N2 |
|---|---|
| Molecular Weight | 238.33 |
| PSA | 16.96000 |
| LogP | 4.72670 |
| Storage condition | 2-8℃ |
| PhiKan 083 |