M8 B hydrochloride
Modify Date: 2024-01-23 07:44:45
M8 B hydrochloride structure
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Common Name | M8 B hydrochloride | ||
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| CAS Number | 883976-12-3 | Molecular Weight | 432.964 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H25ClN2O3S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of M8 B hydrochlorideM8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb)[1]. |
| Name | N-(2-Aminoethyl)-N-[4-(benzyloxy)-3-methoxybenzyl]-2-thiophenecarboxamide hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb)[1]. |
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| Related Catalog | |
| Target |
TRPM8 |
| In Vitro | M8-B (0-100 µM) 以剂量依赖性方式抑制最大 Ca2+ 摄取来抑制 TRPM8 通道活性[1]。 |
| In Vivo | M8-B (6 mg/kg; i.v. or i.p.) 降低大鼠和小鼠的深部体温[1]。 Animal Model: Trpm8+/+ rats and mice[1] Dosage: 6 mg/kg Administration: I.v. or i.p. Result: Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8−/− mice. |
| References |
| Molecular Formula | C22H25ClN2O3S |
|---|---|
| Molecular Weight | 432.964 |
| Exact Mass | 432.127441 |
| RIDADR | NONH for all modes of transport |
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| MFCD27978374 |
| N-(2-Aminoethyl)-N-[4-(benzyloxy)-3-methoxybenzyl]-2-thiophenecarboxamide hydrochloride (1:1) |
| 2-Thiophenecarboxamide, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, hydrochloride (1:1) |