Acid-PEG2-ethyl propionate

Modify Date: 2024-01-11 10:04:28

Acid-PEG2-ethyl propionate Structure
Acid-PEG2-ethyl propionate structure
Common Name Acid-PEG2-ethyl propionate
CAS Number 886362-90-9 Molecular Weight 234.24600
Density 1.145g/cm3 Boiling Point 370.8ºC at 760 mmHg
Molecular Formula C10H18O6 Melting Point N/A
MSDS N/A Flash Point 139.5ºC

 Use of Acid-PEG2-ethyl propionate


Acid-PEG2-ethyl propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 3-(2-(3-Ethoxy-3-oxopropoxy)ethoxy)propanoic acid
Synonym More Synonyms

 Acid-PEG2-ethyl propionate Biological Activity

Description Acid-PEG2-ethyl propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.145g/cm3
Boiling Point 370.8ºC at 760 mmHg
Molecular Formula C10H18O6
Molecular Weight 234.24600
Flash Point 139.5ºC
Exact Mass 234.11000
PSA 82.06000
LogP 0.44750
Index of Refraction 1.452

 Safety Information

Hazard Codes Xi
HS Code 2918990090

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

3-[2-(3-ethoxy-3-oxopropoxy)ethoxy]propanoic acid
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