2-[(4R)-4-Hydroxy-2-oxo-1-pyrrolidinyl]acetamide

Modify Date: 2024-01-02 22:12:00

2-[(4R)-4-Hydroxy-2-oxo-1-pyrrolidinyl]acetamide Structure
2-[(4R)-4-Hydroxy-2-oxo-1-pyrrolidinyl]acetamide structure
Common Name 2-[(4R)-4-Hydroxy-2-oxo-1-pyrrolidinyl]acetamide
CAS Number 88929-35-5 Molecular Weight 158.16
Density 1.4±0.1 g/cm3 Boiling Point 494.6±40.0 °C at 760 mmHg
Molecular Formula C6H10N2O3 Melting Point N/A
MSDS N/A Flash Point 252.9±27.3 °C

 Use of 2-[(4R)-4-Hydroxy-2-oxo-1-pyrrolidinyl]acetamide


(S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke[1].

 Names

Name 1-Pyrrolidineacetamide, 4-hydroxy-2-oxo-, (4S)
Synonym More Synonyms

  Biological Activity

Description (S)-oxiracetam (S-ORC) is an inhibitor targeting apoptosis. S-ORC reduces brain infarct size and lessens neurological dysfunction in middle cerebral artery occlusion/reperfusion (MCAO/R) models. S-ORC prevents neuronal apoptosis via activating PI3K/Akt/GSK3β signaling pathway via α7 nAChR after ischemic stroke. S-ORC can prevent neuronal death after ischemic stroke[1].
Related Catalog
References

[1]. Fan W, et al. S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K / Akt / GSK3β signal pathway in rats. Neurochem Int. 2018 May;115:50-60.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 494.6±40.0 °C at 760 mmHg
Molecular Formula C6H10N2O3
Molecular Weight 158.16
Flash Point 252.9±27.3 °C
Exact Mass 158.069138
PSA 83.63000
LogP -2.48
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.570

 Synonyms

1-PYRROLIDINEACETAMIDE,4-HYDROXY-2-OXO-, (4S)-
(S)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide
2-[(4S)-4-hydroxy-2-oxopyrrolidin-1-yl]acetamide
S-(-)-Oxiracetam
oxiracetam
1-Pyrrolidineacetamide, 4-hydroxy-2-oxo-, (S)-
(S)-Oxiracetam
2-[(4R)-4-Hydroxy-2-oxo-1-pyrrolidinyl]acetamide
(S)-4-Hydroxy-2-oxo-1-pyrrolidineacetamide
1-Pyrrolidineacetamide, 4-hydroxy-2-oxo-, (4R)-
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