4-Chloro-2-nitroaniline

Modify Date: 2024-01-02 16:51:56

4-Chloro-2-nitroaniline Structure
4-Chloro-2-nitroaniline structure
Common Name 4-Chloro-2-nitroaniline
CAS Number 89-63-4 Molecular Weight 172.569
Density 1.5±0.1 g/cm3 Boiling Point 308.8±22.0 °C at 760 mmHg
Molecular Formula C6H5ClN2O2 Melting Point 117-119 °C(lit.)
MSDS Chinese USA Flash Point 140.5±22.3 °C
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger

 Names

Name 4-Chloro-2-nitroaniline
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 308.8±22.0 °C at 760 mmHg
Melting Point 117-119 °C(lit.)
Molecular Formula C6H5ClN2O2
Molecular Weight 172.569
Flash Point 140.5±22.3 °C
Exact Mass 172.003952
PSA 71.84000
LogP 2.74
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.646
Water Solubility INSOLUBLE

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BX1575000
CHEMICAL NAME :
Aniline, 4-chloro-2-nitro-
CAS REGISTRY NUMBER :
89-63-4
BEILSTEIN REFERENCE NO. :
0512436
LAST UPDATED :
199710
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C6-H5-Cl-N2-O2
MOLECULAR WEIGHT :
172.58
WISWESSER LINE NOTATION :
ZR DG BNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
63 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - general anesthetic

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
20 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8936 No. of Facilities: 96 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 17827 (estimated) No. of Female Employees: 16443 (estimated)

 Safety Information

Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H300 + H310 + H330-H373-H411
Precautionary Statements P260-P264-P273-P280-P284-P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T+:Verytoxic;N:Dangerous for the environment;
Risk Phrases R26/27/28;R33;R51/53
Safety Phrases S28-S36/37-S45-S61-S28A
RIDADR UN 2237 6.1/PG 3
WGK Germany 2
RTECS BX1575000
Packaging Group III
Hazard Class 6.1
HS Code 29214210

 Synthetic Route

 Customs

HS Code 2921420090
Summary HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles2

More Articles
[Toxicity of 4-chloro-2-nitroaniline and 2-chloro-4-nitroaniline to isolated rat hepatocytes].

Med. Lav. 82(3) , 253-60, (1991)

The toxicity of 4-chloro-2-nitroaniline (4C2NA) and 2-chloro-4-nitroaniline (2C4NA) was investigated on isolated rat hepatocytes following 1-3 hours of exposure to 0.2 and/or 2 mM of these xenobiotics...

Disposition and metabolism of 4-chloro-2-nitroaniline in the male F344 rat.

J. Toxicol. Environ. Health A 12(2-3) , 267-82, (1983)

The disposition and metabolism of 14C-labeled 4-chloro-2-nitroaniline (CNA) was studied in male F344 rats following oral or intravenous (iv) administration. The gastrointestinal absorption of CNA was ...

 Synonyms

4-chloro-2-nitro-phenylamine
4-chloro-2-nitro-aniline
Red Salt Ciba VI
2-Nitro-4-chloroaniline
Benzenamine,4-chloro-2-nitro
Devol Red Salt F
Red Base Ciba VI
ZR DG BNW
EINECS 201-925-4
1-amino-2-nitro-4-chlorobenzene
MFCD00007836
Benzenamine, 4-chloro-2-nitro-
Aniline,4-chloro-2-nitro
4-Chloro-2-nitroaniline
Red Salt Nbgl
4-Chloro-2-nitrobenzenamine
Devol Red F
Red Base Irga VI
azoamine red 2C
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