Heclin
Modify Date: 2024-01-09 18:12:33
Heclin structure
|
Common Name | Heclin | ||
|---|---|---|---|---|
| CAS Number | 890605-54-6 | Molecular Weight | 283.322 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 495.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H17NO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 253.4±28.7 °C | |
Use of HeclinA small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively; does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys; is active against a range of HECT ligases but does not perturb the ubiquitin system more generally. |
| Name | Heclin |
|---|---|
| Synonym | More Synonyms |
| Description | A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively; does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys; is active against a range of HECT ligases but does not perturb the ubiquitin system more generally. |
|---|---|
| References | References 1. Mund T, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41. View Related Products by Target E3 Ubiquitin Ligase |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 495.4±45.0 °C at 760 mmHg |
| Molecular Formula | C17H17NO3 |
| Molecular Weight | 283.322 |
| Flash Point | 253.4±28.7 °C |
| Exact Mass | 283.120850 |
| LogP | 4.22 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.615 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
|---|
| Heclin |
| 2-Propenamide, N-(4-acetylphenyl)-3-(5-ethyl-2-furanyl)-, (2E)- |
| (2E)-N-(4-Acetylphenyl)-3-(5-ethyl-2-furyl)acrylamide |
| N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Heclin
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Heclin
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: Heclin
- Price: $Inquiry/25mg $Inquiry/100mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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