890605-54-6

890605-54-6 structure

Name: Heclin
Chemical Name: Heclin
CAS Number: 890605-54-6
Molecular Formula: C₁₇H₁₇NO₃
Molecular Weight: 283.322
Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
Create Date: 2020-01-12 11:04:26
Modify Date: 2024-01-09 18:12:33
A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively; does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys; is active against a range of HECT ligases but does not perturb the ubiquitin system more generally.

Name	Heclin
Synonyms	Heclin 2-Propenamide, N-(4-acetylphenyl)-3-(5-ethyl-2-furanyl)-, (2E)- (2E)-N-(4-Acetylphenyl)-3-(5-ethyl-2-furyl)acrylamide N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

Description	A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively; does not block E2 binding but causes a conformational change that results in oxidation of the active site Cys; is active against a range of HECT ligases but does not perturb the ubiquitin system more generally.
References	References 1. Mund T, et al. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41. View Related Products by Target E3 Ubiquitin Ligase

RIDADR	NONH for all modes of transport