Atrial Natriuretic Factor (1-28) (human) acetate salt

Modify Date: 2024-01-09 19:51:40

Atrial Natriuretic Factor (1-28) (human) acetate salt structure	Common Name	Atrial Natriuretic Factor (1-28) (human) acetate salt
	CAS Number	89213-87-6	Molecular Weight	3080.444
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₂₇H₂₀₃N₄₅O₃₉S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Atrial Natriuretic Factor (1-28) (human) acetate salt

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibits endothelin-1 secretion in a dose-dependent way.

Name	anp 1-28, human
Synonym	More Synonyms

Description	Atrial Natriuretic Peptide (ANP) (1-28), human, porcine is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibits endothelin-1 secretion in a dose-dependent way.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor Peptides Research Areas >> Cardiovascular Disease
Target	Endothelin-1[1]
In Vitro	Atrial natriuretic peptide (ANP) is a diuretic, natriuretic, and vasodilatory peptide hormone originally isolated from mammalian hearts. In cultured porcine endothelial cells the inhibition by porcine ANP (1-28) of immunoreactive endothelin-1 secretion after stimulation with Angiotensin II (Ang II) is paralleled by an increase in the cellular cGMP level. Porcine ANP (1-28) strongly inhibits immunoreactive endothelin-1 secretion in porcine aorta after stimulation with Ang II[1]. ANP is a cardiac hormone involved in electrolyte and fluid homeostasis. The inhibition by ANP of endothelin-1 secretion stimulated by angiotensin II (ANGII) and thrombin using cultured human umbilical-vein endothelial cells. Human ANP (1-28) inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells[2]. In glomeruli from normal rats, Human 125I-ANP (1-28) binds to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human ANP (1-28) binds to the glomerular ANP receptor with high affinity stimulated cGMP accumulation. Human ANP (1-28) markedly stimulates cGMP generation, but not cAMP generation in normal rat glomeruli[3].
References	[1]. Kohno M, et al. Atrial and brain natriuretic peptides inhibit the endothelin-1 secretory response to angiotensin II in porcine aorta. Circ Res. 1992 Feb;70(2):241-7. [2]. Kohno M, et al. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest. 1991 Jun;87(6):1999-2004. [3]. Ballermann BJ, et al. Physiologic regulation of atrial natriuretic peptide receptors in rat renal glomeruli. J Clin Invest. 1985 Dec;76(6):2049-56.

Density	1.6±0.1 g/cm3
Molecular Formula	C₁₂₇H₂₀₃N₄₅O₃₉S₃
Molecular Weight	3080.444
Exact Mass	3078.444580
PSA	1479.28000
LogP	-14.30
Index of Refraction	1.689

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CJ9920000

CHEMICAL NAME :: Atriopeptin-33(rat), 1-de-L-leucine-2-de-L-alanine-3-deglycine-4-de-L-prol ine-5-de-L-arginine-1 7-L-methionine-

CAS REGISTRY NUMBER :: 89213-87-6

LAST UPDATED :: 199406

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: Cl27-H203-N45-O39-S3

MOLECULAR WEIGHT :: 2512.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 110 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - behavioral

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 44,495,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 840 mg/kg

SEX/DURATION :: male 9 week(s) pre-mating female 2 week(s) pre-mating - 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 44,485,1992

Atrial natriuretic peptide (human, 1-28)

α-Humanatrial natriuretic peptide

ANP1-28,HUMAN

HSCH2CH2(NHCO)2(CH2)2CH(CH3)2

α-ANF (1-28), human

Atrial natriuretic peptide-28 (human)

carperitide

Pentanamide,N-[[(2-mercaptoethyl)amino]carbonyl]-4-methyl

(1-28)-Human atrial natriuretic peptide

H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH

L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanylglycylglycyl-L-arginyl-L-methionyl-L-aspartyl-L-arginyl-L-isoleucylglycyl-L-alanyl-L-glutaminyl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-asparaginyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine cyclic (7->23)-disulfide

Atrial Natriuretic Peptide (1-28), human

Atrial Natriuretic Peptide (ANP) (1-28), human, porcine