Michler's ketone

Modify Date: 2024-01-07 09:15:35

Michler's ketone structure	Common Name	Michler's ketone
	CAS Number	90-94-8	Molecular Weight	268.353
	Density	1.1±0.1 g/cm3	Boiling Point	427.7±30.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₂₀N₂O	Melting Point	174 -176 °C(lit.)
	MSDS	Chinese USA	Flash Point	183.9±16.9 °C
	Symbol	GHS05, GHS08	Signal Word	Danger

Name	4,4'-Bis(dimethylamino)benzophenone
Synonym	More Synonyms

Density	1.1±0.1 g/cm3
Boiling Point	427.7±30.0 °C at 760 mmHg
Melting Point	174 -176 °C(lit.)
Molecular Formula	C₁₇H₂₀N₂O
Molecular Weight	268.353
Flash Point	183.9±16.9 °C
Exact Mass	268.157562
PSA	23.55000
LogP	3.87
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.612
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, strong reducing agents.
Water Solubility	400 mg/L (20 ºC)

Michler's ketone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ0250000

CHEMICAL NAME :: Benzophenone, 4,4'-bis(dimethylamino)-

CAS REGISTRY NUMBER :: 90-94-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C17-H20-N2-O

MOLECULAR WEIGHT :: 268.39

WISWESSER LINE NOTATION :: 1N1&R D- 2V

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 164 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Liver - tumors

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 1500 ug/L

REFERENCE :: MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 1,17,1986 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1044 No. of Facilities: 174 (estimated) No. of Industries: 7 No. of Occupations: 11 No. of Employees: 2026 (estimated) No. of Female Employees: 405 (estimated)

Symbol	GHS05, GHS08
Signal Word	Danger
Hazard Statements	H318-H341-H350
Precautionary Statements	P201-P280-P305 + P351 + P338-P308 + P313
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R41;R45;R68
Safety Phrases	S53-S45
RIDADR	2811
WGK Germany	3
RTECS	DJ0250000
Packaging Group	III
Hazard Class	6.1
HS Code	2922399090

Precursor 8
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DownStream 9
CAS#:81260-56-2 4-(N-methylamin... CAS#:611-98-3 4,4'-Diaminoben... CAS#:3708-39-2 4,4'-BIS(METHYL... CAS#:81260-55-1 (4-dimethylamin...
CAS#:64-19-7 acetic acid CAS#:116-09-6 acetol CAS#:100-61-8 N-Methylaniline CAS#:5809-25-6 (4-aminophenyl)...
CAS#:492-80-8 Yellow pyoctanine

HS Code	2922399090
Summary	2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Determination of xenobiotic intrinsic clearance in freshly isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) and rat and its application in bioaccumulation assessment.

Environ. Sci. Technol. 41(9) , 3269-76, (2007)

Bioaccumulation in fish depends on the dynamics of various processes that involve fish uptake, storage, and elimination of xenobiotics. Elimination via fish biotransformation is a primary process that...

A comparison of the mutagenicity and macromolecular binding of the carcinogens Michler's ketone and reduced Michler's ketone.

Mutat. Res. 119(1) , 7-14, (1983)

The mutagenicity of 4,4'-bis(dimethylamino)benzophenone (Michler's ketone, MK, CAS No. 90-94-8) and 4,4'-methylenebis(N,N-dimethyl)benzamine (reduced Michler's ketone, RMK, CAS No. 101-61-1) for Salmo...

Michler's ketone.

Rep. Carcinog. 12 , 270-1, (2011)

4,4'-Bis(dimethylamino)benzophenone

Bis[p-(N,N-dimethylamino)phenyl] ketone

EINECS 202-027-5

Methanone, bis[4- (dimethylamino)phenyl]-

Methanone, bis[4-(dimethylamino)phenyl]-

Bis[4-(dimethylamino)phenyl]methanone

Michler's ketone

MFCD00008312

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Michler's ketone
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Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Michler's ketone
Price: ￥138.0/100g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4,4'-Bis(dimethylamino)benzophenone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 90-94-8
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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