Pectin

Modify Date: 2024-01-02 12:13:13

Pectin Structure
Pectin structure
 Common Name Pectin
CAS Number 9000-69-5 Molecular Weight 150.130
Density 1.5±0.1 g/cm3 Boiling Point 415.5±38.0 °C at 760 mmHg
Molecular Formula C5H10O5 Melting Point 6.1ºC
MSDS Chinese USA Flash Point 219.2±23.3 °C

 Use of Pectin


Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of drugs. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa[1][2][3].

 Names

Name pectin
Synonym More Synonyms

 Pectin Biological Activity

Description Pectin is a heteropolysaccharide, derived from the cell wall of higher plants. Pectin involves in the formation of nanoparticles as a delivery vehicle of drugs. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa[1][2][3].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Pectin (5 mg/mL; 24, 48, and 72 h) shows low cytotoxicity on HepG2 cells, and can be made into nanoparticles (PPN), encapsulating Paclitaxel (HY-B0015), decreases the Paclitaxel cytotoxicity (%) from 55.6% to 21.7% at 72 h[1]. Pectin (3, 6 mg/mL; 48 h) inhibits Staphylococcus aureus ATCC 25923 growth, with a minimum inhibitory concentration (MIC) of 40 mg/mL[2]. Pectin inhibits Gram-negative Helicobacter pylori, a common human pathogen, shows highest antibacterial activity at pH 5.0, with a minimum inhibitory concentration (MIC) of 0.162 mg/mL and minimum bactericidal concentration (MBC) of 0.325 mg/mL[2]. Pectin displays lower antibacterial activity against E. coli with MICs of 25 mg/mL and 50 mg/mL and MBC values ranging between 25-50 mg/mL[2]. Pectin exhibits the antibacterial activity via its undissociated acid form[2].
In Vivo Pectin serves as the nanoparticles encapsulating Paclitaxel (HY-B0015), (20 mg/kg; i.v.; single dose) significantly delays plasma clearance with detection of Paclitaxel possible up to 48 h in Balb/c mice[1].
References

[1]. Verma AK, et al. Pharmacokinetics and biodistribution of negatively charged pectin nanoparticles encapsulating paclitaxel. Cancer Nanotechnol. 2013;4(4-5):99-102. 

[2]. Ciriminna R, et al. Pectin: A Long-Neglected Broad-Spectrum Antibacterial. ChemMedChem. 2020 Dec 3;15(23):2228-2235. 

[3]. Wikiera A, et al. Prozdrowotne właściwości pektyn [Health-promoting properties of pectin]. Postepy Hig Med Dosw (Online). 2014 Jan 2;68:590-6. Polish.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 415.5±38.0 °C at 760 mmHg
Melting Point 6.1ºC
Molecular Formula C5H10O5
Molecular Weight 150.130
Flash Point 219.2±23.3 °C
Exact Mass 150.052826
PSA 97.99000
LogP -2.39
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.544
Storage condition 2-8°C
Water Solubility H2O: soluble0.02g/10 mL, clear to hazy, colorless to very faintly yellow | It is soluble in water.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RX4280000
CHEMICAL NAME :
Pectin
CAS REGISTRY NUMBER :
9000-69-5
LAST UPDATED :
199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 13,29,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(1),58S,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84368 No. of Facilities: 1645 (estimated) No. of Industries: 6 No. of Occupations: 13 No. of Employees: 16045 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7456 No. of Facilities: 1936 (estimated) No. of Industries: 9 No. of Occupations: 19 No. of Employees: 54050 (estimated) No. of Female Employees: 46189 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S24/25
RIDADR NONH for all modes of transport
RTECS RX4280000
HS Code 1302200000

 Customs

HS Code 1302200000

 Articles75

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 Synonyms

gentisic acid dimethyl ether
Dimethylaethergentisinsaeure
6-methoxy-m-anisic acid
2,5-dimethoxy-benzoic acid
2,5-dimethoxylbenzoic acid
Benzoic acid,2,5-dimethoxy
EINECS 232-553-0
2,5-Dimethoxy-benzoesaeure
Pentose
MFCD00081838
2,5-bis-methoxybenzoic acid
GENU Pectin USP-H
polygalacturonic acid
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