ALR-27

Modify Date: 2024-01-12 10:26:11

ALR-27 structure	Common Name	ALR-27
	CAS Number	903639-13-4	Molecular Weight	298.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ALR-27

ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes[1].

Name	ALR-27

Description	ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> FLAP Research Areas >> Inflammation/Immunology
Target	FLAP[1]
References	[1]. Cerchia C et al. Identification of selective 5-LOX and FLAP inhibitors as novel anti-inflammatory agents by ligand-based virtual screening. Eur J Med Chem. 2023 Nov 8;263:115932.

Molecular Formula	C₁₉H₂₂O₃
Molecular Weight	298.38

ALR-27

Use of ALR-27

Names

ALR-27 Biological Activity

Chemical & Physical Properties