Xaliproden hydrochloride
Xaliproden hydrochloride structure
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Common Name | Xaliproden hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 90494-79-4 | Molecular Weight | 417.89400 | |
| Density | N/A | Boiling Point | 487.8ºC at 760mmHg | |
| Molecular Formula | C24H23ClF3N | Melting Point | N/A | |
| MSDS | USA | Flash Point | 248.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Xaliproden hydrochlorideXaliproden hydrochloride (SR57746A) is a potent, selective and orally active agonist of 5-HT1A receptor, shows a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50=3 nM). Xaliproden hydrochloride is also a selective antagonist of dopamine D2 receptor, has moderate affinity (IC50=0.1-1 μM). Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects, and it may possess therapeutic potential for the research of neurodegenerative diseases[1][2][3]. |
| Name | 1-(2-naphthalen-2-ylethyl)-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-pyridine,hydrochloride |
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| Synonym | More Synonyms |
| Description | Xaliproden hydrochloride (SR57746A) is a potent, selective and orally active agonist of 5-HT1A receptor, shows a high affinity for 5-HT1A specific binding sites in the rat hippocampus (IC50=3 nM). Xaliproden hydrochloride is also a selective antagonist of dopamine D2 receptor, has moderate affinity (IC50=0.1-1 μM). Xaliproden hydrochloride exhibits anti-depression and anti-anxiety effects, and it may possess therapeutic potential for the research of neurodegenerative diseases[1][2][3]. |
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| Related Catalog | |
| Target |
5-HT1A Receptor:3 nM (IC50) D2 Receptor:0.1-1 μM (IC50) |
| References |
| Boiling Point | 487.8ºC at 760mmHg |
|---|---|
| Molecular Formula | C24H23ClF3N |
| Molecular Weight | 417.89400 |
| Flash Point | 248.8ºC |
| Exact Mass | 417.14700 |
| PSA | 3.24000 |
| LogP | 6.93030 |
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5-HT1A receptors are involved in the effects of xaliproden on G-protein activation, neurotransmitter release and nociception.
Br. J. Pharmacol. 158(1) , 232-42, (2009) Xaliproden (SR57746A) is a 5-HT(1A) receptor agonist and neurotrophic agent that reduces oxaliplatin-mediated neuropathy in clinical trials. The present study investigated its profile on in vitro tran... |
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Magnetic resonance imaging of the neuroprotective effect of xaliproden in rats.
Invest. Radiol. 37(6) , 321-7, (2002) The neurotrophic effect of Xaliproden has been followed using sequential cerebral magnetic resonance imaging (MRI) in rats with vincristine-induced brain lesion as a model of Alzheimer disease.Ninetee... |
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The neuroprotective agent SR 57746A abrogates experimental autoimmune encephalomyelitis and impairs associated blood-brain barrier disruption: implications for multiple sclerosis treatment.
Proc. Natl. Acad. Sci. U. S. A. 96(22) , 12855-9, (1999) Experimental autoimmune encephalomyelitis (EAE) is a T cell autoimmune disorder that is a widely used animal model for multiple sclerosis (MS) and, as in MS, clinical signs of EAE are associated with ... |
| Xaliproden hydrochloride |