Diprotin B

Modify Date: 2024-01-09 21:59:14

Diprotin B Structure
Diprotin B structure
Common Name Diprotin B
CAS Number 90614-49-6 Molecular Weight 327.41900
Density 1.157 g/cm3 Boiling Point 575.9ºC at 760 mmHg
Molecular Formula C16H29N3O4 Melting Point N/A
MSDS N/A Flash Point 302.1ºC

 Use of Diprotin B


Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue[1][2].

 Names

Name 2-[[1-(2-amino-3-methylbutanoyl)pyrrolidine-2-carbonyl]amino]-4-methylpentanoic acid
Synonym More Synonyms

 Diprotin B Biological Activity

Description Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue[1][2].
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 Chemical & Physical Properties

Density 1.157 g/cm3
Boiling Point 575.9ºC at 760 mmHg
Molecular Formula C16H29N3O4
Molecular Weight 327.41900
Flash Point 302.1ºC
Exact Mass 327.21600
PSA 112.73000
LogP 1.60530
Index of Refraction 1.519

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OH3350000
CHEMICAL NAME :
L-Leucine, N-(1-L-valyl-L-prolyl)-
CAS REGISTRY NUMBER :
90614-49-6
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H29-N3-O4
MOLECULAR WEIGHT :
327.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,422,1984

 Safety Information

Hazard Codes Xn

 Synonyms

L-valyl-L-prolyl-L-leucine
VAL-PRO-LEU
Diprotin B
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