GAMMA-CARRAGEENAN

Modify Date: 2024-01-14 18:06:46

GAMMA-CARRAGEENAN Structure
GAMMA-CARRAGEENAN structure
Common Name GAMMA-CARRAGEENAN
CAS Number 9064-57-7 Molecular Weight 1140.91000
Density N/A Boiling Point N/A
Molecular Formula C24H36O39S6 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of GAMMA-CARRAGEENAN


λ-Carrageenan is a seaweed polysaccharide which has been generally used as proinflammatory agent in the basic research. λ-Carrageenan is a potent antitumor agent[1].

 Names

Name λ-carrageenan
Synonym More Synonyms

 GAMMA-CARRAGEENAN Biological Activity

Description λ-Carrageenan is a seaweed polysaccharide which has been generally used as proinflammatory agent in the basic research. λ-Carrageenan is a potent antitumor agent[1].
Related Catalog
In Vivo λ-Carrageenan (50 mg/kg every two days; intratumoral injection) inhibits tumor growth in B16-F10 and 4T1 bearing mice[1]. λ-carrageenan exhibits considerable antitumor effect via intratumoral injection and significantly improves the tumor immune response with increased infiltrates of immunostimulating cells and increases production of proinflammatory cytokines[1].
References

[1]. Luo M, et al. Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy. Sci Rep. 2015;5:11062. Published 2015 Jun 22.

 Chemical & Physical Properties

Molecular Formula C24H36O39S6
Molecular Weight 1140.91000
Exact Mass 1139.92000
PSA 675.31000

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FI0704000
CHEMICAL NAME :
lambda-Carrageenan
CAS REGISTRY NUMBER :
9064-57-7
LAST UPDATED :
199512

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Vascular - thrombosis distant from injection site Liver - hepatitis (hepatocellular necrosis), zonal Liver - other changes
REFERENCE :
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year: 57,455,1976
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Blood - change in clotting factors
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 17,647,1965

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
RTECS FI0704000

 Articles9

More Articles
Layer-by-layer assembled cell instructive nanocoatings containing platelet lysate.

Biomaterials 48 , 56-65, (2015)

Great efforts have been made to introduce growth factors (GFs) onto 2D/3D constructs in order to control cell behavior. Platelet lysate (PL) presents itself as a cost-effective source of multiple GFs ...

Self-assembled carrageenan/protamine polyelectrolyte nanoplexes-Investigation of critical parameters governing their formation and characteristics.

Carbohydr. Polym. 123 , 339-49, (2015)

The aim of this work was to investigate the feasibility of cross-linker free polyelectrolyte complex formation at the nanoscale between carrageenan (CAR) and protamine (PROT). The properties of CAR/PR...

Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model.

J. Nat. Prod. 75 , 54-59, (2012)

Sclareol (1) is a natural fragrance compound used widely in the cosmetic and food industries. Lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and the λ-carrageenan-induced edema mouse paw mod...

 Synonyms

MFCD00151513
lambda-carrageenan
λ-Carrageenan
2-O-Sulfonato-β-D-galactopyranosyl-(1->4)-2,6-di-O-sulfonato-α-D-galactopyranosyl-(1->3)-2-O-sulfonato-β-D-galactopyranosyl-(1->4)-2,6-di-O-sulfonato-α-D-galactopyranose
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