tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[chromene-2,4'-piperidine]-1'-carboxylate

Modify Date: 2024-01-02 15:52:26

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[chromene-2,4'-piperidine]-1'-carboxylate Structure
tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[chromene-2,4'-piperidine]-1'-carboxylate structure
Common Name tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[chromene-2,4'-piperidine]-1'-carboxylate
CAS Number 911228-63-2 Molecular Weight 427.34100
Density 1.151g/cm3 Boiling Point 502.643ºC at 760 mmHg
Molecular Formula C24H34BNO5 Melting Point N/A
MSDS N/A Flash Point 257.789ºC

 Names

Name tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[chromene-2,4'-piperidine]-1'-carboxylate

 Chemical & Physical Properties

Density 1.151g/cm3
Boiling Point 502.643ºC at 760 mmHg
Molecular Formula C24H34BNO5
Molecular Weight 427.34100
Flash Point 257.789ºC
Exact Mass 427.25300
PSA 57.23000
LogP 4.80140
Index of Refraction 1.549

 Safety Information

HS Code 2934999090

 Synthetic Route

~93%

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[chromene-2,4'-piperidine]-1'-carboxylate Structure

tert-butyl 4-(4...

CAS#:911228-63-2

Literature: Bourdonnec, Bertrand Le; Windh, Rolf T.; Leister, Lara K.; Zhou, Q. Jean; Ajello, Christopher W.; Gu, Minghua; Chu, Guo-Hua; Tuthill, Paul A.; Barker, William M.; Koblish, Michael; Wiant, Daniel D.; Graczyk, Thomas M.; Belanger, Serge; Cassel, Joel A.; Feschenko, Marina S.; Brogdon, Bernice L.; Smith, Steven A.; Derelanko, Michael J.; Kutz, Steve; Little, Patrick J.; Dehaven, Robert N.; DeHaven-Hudkins, Diane L.; Dolle, Roland E. Journal of Medicinal Chemistry, 2009 , vol. 52, # 18 p. 5685 - 5702

~%

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[chromene-2,4'-piperidine]-1'-carboxylate Structure

tert-butyl 4-(4...

CAS#:911228-63-2

Literature: MERCK FROSST CANADA LTD.; LECLERC, Jean-Philippe; LI, Chun, Sing; MORADEI, Oscar, Miguel Patent: WO2011/11872 A1, 2011 ; WO 2011/011872 A1

~%

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[chromene-2,4'-piperidine]-1'-carboxylate Structure

tert-butyl 4-(4...

CAS#:911228-63-2

Literature: MERCK FROSST CANADA LTD.; LECLERC, Jean-Philippe; LI, Chun, Sing; MORADEI, Oscar, Miguel Patent: WO2011/11872 A1, 2011 ; WO 2011/011872 A1

~%

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[chromene-2,4'-piperidine]-1'-carboxylate Structure

tert-butyl 4-(4...

CAS#:911228-63-2

Literature: MERCK FROSST CANADA LTD.; LECLERC, Jean-Philippe; LI, Chun, Sing; MORADEI, Oscar, Miguel Patent: WO2011/11872 A1, 2011 ; WO 2011/011872 A1

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%