LY83583

Modify Date: 2024-01-03 15:10:03

LY83583 Structure
LY83583 structure
Common Name LY83583
CAS Number 91300-60-6 Molecular Weight 250.252
Density 1.4±0.1 g/cm3 Boiling Point 446.9±45.0 °C at 760 mmHg
Molecular Formula C15H10N2O2 Melting Point 184-185°C
MSDS USA Flash Point 224.1±28.7 °C

 Use of LY83583


LY83583 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM[1].

 Names

Name 6-anilino-5,8-quinolinedione
Synonym More Synonyms

 LY83583 Biological Activity

Description LY83583 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM[1].
Related Catalog
References

[1]. Mülsch A, et al. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):119-25.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 446.9±45.0 °C at 760 mmHg
Melting Point 184-185°C
Molecular Formula C15H10N2O2
Molecular Weight 250.252
Flash Point 224.1±28.7 °C
Exact Mass 250.074234
PSA 59.06000
LogP 1.56
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.715
Storage condition 2-8°C
Water Solubility 0.1 M HCl: 1 mg/mL

 Safety Information

Hazard Codes Xn: Harmful;
Risk Phrases R40
Safety Phrases S36/37
RIDADR NONH for all modes of transport
WGK Germany 2
HS Code 2933499090

 Synthetic Route

~61%

LY83583 Structure

LY83583

CAS#:91300-60-6

Literature: Jiang, Chunhui; Wang, Shaozhong Synlett, 2009 , # 7 p. 1099 - 1102

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LY83583 Structure

LY83583

CAS#:91300-60-6

Literature: Chemische Berichte, , vol. 17, p. 1645

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LY83583 Structure

LY83583

CAS#:91300-60-6

Literature: Chemische Berichte, , vol. 17, p. 1645

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles33

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Plant Mol. Biol. 81(1-2) , 27-40, (2013)

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 Synonyms

6-anilinoquinoline-5,8-dione
6-(Phenylamino)quinoline-5,8-dione
5,8-Quinolinedione, 6-(phenylamino)-
6-ANILINO-5,8-QUINOLINEDIONE
MFCD00210756
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