CCMI

Modify Date: 2024-01-11 16:14:10

CCMI Structure
CCMI structure
Common Name CCMI
CAS Number 917837-54-8 Molecular Weight 388.24700
Density 1.412±0.06 g/cm3(Predicted) Boiling Point 605.4±55.0 °C
Molecular Formula C19H15Cl2N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CCMI


CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].

 Names

Name (Z)-3-(4-chloroanilino)-N-(4-chlorophenyl)-2-(3-methyl-1,2-oxazol-5-yl)prop-2-enamide
Synonym More Synonyms

 CCMI Biological Activity

Description CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. CCMI has potential in CNS diseases with cognitive dysfunction[1].
Related Catalog
Target

α7 nAChR[1]

In Vitro CCMI (Compound 6) is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs[1].
References

[1]. Ng HJ, et al. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64. Epub 2007 Apr 30.

 Chemical & Physical Properties

Density 1.412±0.06 g/cm3(Predicted)
Boiling Point 605.4±55.0 °C
Molecular Formula C19H15Cl2N3O2
Molecular Weight 388.24700
Exact Mass 387.05400
PSA 67.16000
LogP 5.52750

 Safety Information

Hazard Codes Xn

 Synonyms

MFCD18086897