AZD-1656
Modify Date: 2024-01-01 19:58:38
AZD-1656 structure
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Common Name | AZD-1656 | ||
|---|---|---|---|---|
| CAS Number | 919783-22-5 | Molecular Weight | 478.500 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 635.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C24H26N6O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 337.8±31.5 °C | |
Use of AZD-1656AZD1656 is a potent, selective and orally active glucokinase activator with an EC50 of 60 nM. AZD1656 has the potential for type 2 diabetes research[1][2][3]. |
| Name | AZD1656 |
|---|---|
| Synonym | More Synonyms |
| Description | AZD1656 is a potent, selective and orally active glucokinase activator with an EC50 of 60 nM. AZD1656 has the potential for type 2 diabetes research[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 60 nM (Glucokinase)[2] |
| In Vivo | AZD1656 (0-9 mg/kg; oral gavage; daily; for 8 weeks; C57BL/6 mice) treatment shows lowered blood glucose and glucose excursion and raised insulin. Liver mRNA levels for various ChREBP target genes including carbohydrate response element binding protein beta isoform (ChREBP-β), G6pc, Pklr, Acly, Acac and Gpd2 are increased by AZD1656[1]. Animal Model: C57BL/6 mice[1] Dosage: 0 mg/kg, 2 mg/kg, 4.5 mg/kg, 9 mg/kg Administration: Oral gavage; daily; for 8 weeks Result: Administered 2 hours before the oral glucose tolerance test, lowered blood glucose and glucose excursion and raised insulin. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 635.0±55.0 °C at 760 mmHg |
| Molecular Formula | C24H26N6O5 |
| Molecular Weight | 478.500 |
| Flash Point | 337.8±31.5 °C |
| Exact Mass | 478.196472 |
| LogP | -0.21 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.631 |
| Storage condition | -20℃ |
| 660M185X4D |
| 3-{[5-(1-Azetidinylcarbonyl)-2-pyrazinyl]oxy}-5-{[(2S)-1-methoxy-2-propanyl]oxy}-N-(5-methyl-2-pyrazinyl)benzamide |
| AZD1656 |
| Benzamide, 3-[[5-(1-azetidinylcarbonyl)-2-pyrazinyl]oxy]-5-[(1S)-2-methoxy-1-methylethoxy]-N-(5-methyl-2-pyrazinyl)- |