4-(6-Methyl-2-benzothiazolyl)benzeneamine

Modify Date: 2024-01-05 19:41:46

4-(6-Methyl-2-benzothiazolyl)benzeneamine structure	Common Name	4-(6-Methyl-2-benzothiazolyl)benzeneamine
	CAS Number	92-36-4	Molecular Weight	240.32300
	Density	1.264 g/cm3	Boiling Point	434°C
	Molecular Formula	C₁₄H₁₂N₂S	Melting Point	191-196°C
	MSDS	Chinese USA	Flash Point	217.3ºC
	Symbol	GHS07	Signal Word	Warning

Use of 4-(6-Methyl-2-benzothiazolyl)benzeneamine

Dehydrothio-p-toluidine (DHPT) is a chemical intermediate used in dyestuff production. Dehydrothio-p-toluidine shows inhalation toxicity in acute and subchronic conditions[1].

Name	2-(4-Aminophenyl)-6-methylbenzothiazole
Synonym	More Synonyms

Description	Dehydrothio-p-toluidine (DHPT) is a chemical intermediate used in dyestuff production. Dehydrothio-p-toluidine shows inhalation toxicity in acute and subchronic conditions[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vivo	Dehydrothio-p-toluidine (4 h) induces salivation, pawing and chewing motions, lachrymation, sporadic fasciculations, rapid respiration and slight weight loss of mice under an average of 0.64 mg DHPT/L condition[1]. Dehydrothio-p-toluidine (4 h) induces sporadic nasal discharge and lethargy of mice under an average of 2.41 mg DHPT/L condition[1]. Dehydrothio-p-toluidine (6 h/day on 5 days followed by two rest days and then by five additional days of exposures; 0.6 mg DHPT/L) decreases the erythrocyte count, haemoglobin level and relative number of lymphocytes than in the controls, excrets a larger volume of less-concentrated urine, produces liver changes characterized by hepatocyte hyper trophy and proliferation of bile-duct epithelial cells and induxes thymic necrosis and depletion of lymphocytes after the tenth exposure[1].

Density	1.264 g/cm3
Boiling Point	434°C
Melting Point	191-196°C
Molecular Formula	C₁₄H₁₂N₂S
Molecular Weight	240.32300
Flash Point	217.3ºC
Exact Mass	240.07200
PSA	67.15000
LogP	4.43510
Index of Refraction	1.709
Water Solubility	<0.1 g/100 mL at 20 ºC

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Product Name: 4-(6-Methyl-2-benzothiazolyl)benzeneamine
Synonyms:

Section2. Hazards identiﬁcation
Harmful by inhalation, in contact with skin, and if swallowed.

Section3. Composition/information on ingredients.
Ingredient name:4-(6-Methyl-2-benzothiazolyl)benzeneamine
CAS number:92-36-4

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not speciﬁed
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C14H12N2S
Molecular weight:240.3

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL2820000

CHEMICAL NAME :: Benzothiazole, 2-(p-aminophenyl)-6-methyl-

CAS REGISTRY NUMBER :: 92-36-4

BEILSTEIN REFERENCE NO. :: 0175967

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H12-N2-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/m3/4H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,289,1984 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 68 gm/m3/6H/12D-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Blood - changes in erythrocyte (RBC) count

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,289,1984

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26;S36
RIDADR	NONH for all modes of transport
RTECS	DL2820000
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Inhalation toxicity of dehydrothio-p-toluidine.

Food Chem. Toxicol. 22(4) , 289-92, (1984)

The acute inhalation toxicity of dehydrothio -p-toluidine ( DHPT ; CAS Registry No. 92-36-4) was determined by exposing groups of young adult Crl-CD rats for single 4-hr periods. Death resulted when t...

MFCD00005780

EINECS 202-150-4

4-(6-methyl-1,3-benzothiazol-2-yl)aniline