(Z)-Cefprozil

Modify Date: 2024-01-02 11:47:46

(Z)-Cefprozil Structure
(Z)-Cefprozil structure
 Common Name (Z)-Cefprozil
CAS Number 92665-29-7 Molecular Weight 389.426
Density 1.5±0.1 g/cm3 Boiling Point 803.1±65.0 °C at 760 mmHg
Molecular Formula C18H19N3O5S Melting Point 76°C
MSDS N/A Flash Point 439.5±34.3 °C

 Use of (Z)-Cefprozil


Cefprozil (Cefzil) is a second-generation cephalosporin type antibiotic[1].

 Names

Name cefprozil
Synonym More Synonyms

 (Z)-Cefprozil Biological Activity

Description Cefprozil (Cefzil) is a second-generation cephalosporin type antibiotic[1].
Related Catalog

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 803.1±65.0 °C at 760 mmHg
Melting Point 76°C
Molecular Formula C18H19N3O5S
Molecular Weight 389.426
Flash Point 439.5±34.3 °C
Exact Mass 389.104553
PSA 158.26000
LogP 0.06
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.718
Storage condition -20°C Freezer
Water Solubility 3.3 mg/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XI0339000
CHEMICAL NAME :
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl) amino)-8-oxo-3-(1-propenyl)-, (6R-(6-alpha,7-beta(R*)))-, hydrate
CAS REGISTRY NUMBER :
92665-29-7
LAST UPDATED :
199703
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C18-H19-N3-O5-S.H2-O
MOLECULAR WEIGHT :
407.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
100 mg/kg/5D-I
TOXIC EFFECTS :
Musculoskeletal - joints Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 125,325,1994
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
7500 ug/kg/5D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Musculoskeletal - joints Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 125,325,1994
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1238,1990
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1238,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
21 gm/kg/4W-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1243,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
14 gm/kg/4W-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1260,1990

 Safety Information

Hazard Codes Xn
Risk Phrases R22:Harmful if swallowed. R41:Risk of serious damage to eyes. R43:May cause sensitization by skin contact.
Safety Phrases S26-S36/37/39
RTECS XZ4380000
HS Code 2941905990

 Customs

HS Code 2941905990

 Synonyms

Cefprozil
Prozef
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1Z)-1-propen-1-yl]-, (6R,7R)-
5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1Z)-1-propenyl]-, (6R,7R)-
Cefrozil
(6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(1Z)-prop-1-en-1-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CEFPROZIL , (Z)-
(6R,7R)-7-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(1Z)-1-propen-1-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Cephprozyl
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-8-oxo-3-(1-propenyl)-, (6R,7R)-
MFCD00865082
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