IA-Alkyne
Modify Date: 2024-01-11 20:26:52
IA-Alkyne structure
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Common Name | IA-Alkyne | ||
|---|---|---|---|---|
| CAS Number | 930800-38-7 | Molecular Weight | 265.09100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H12INO | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of IA-AlkyneIA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection[1]. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling[2]. |
| Name | N-(5-Hexyn-1-yl)-2-iodoacetamide |
|---|---|
| Synonym | More Synonyms |
| Description | IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection[1]. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling[2]. |
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| Related Catalog | |
| Target |
IC50: TRPC[1] |
| In Vitro | IA-alkyne (2.5-10 μM; 1 hour) can react with cysteines. Soluble fractions of HeLa cell lysates (2.0 mg/ml) are treated with IA-alkyne. Labeled proteome samples are conjugated with a fluorescent rhodamine-azide tag through CuAAC, and analyzed by SDS-PAGE. In-gel fluorescence imaging reveals that IA-alkyne has a strong fluorescent intensity[2]. |
| References |
[1]. David L. Use of trp channel agonists to treat infections. Patent US20130203715A1. |
| Molecular Formula | C8H12INO |
|---|---|
| Molecular Weight | 265.09100 |
| Exact Mass | 264.99600 |
| PSA | 32.59000 |
| LogP | 2.18140 |
| Hazard Codes | T+ |
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| MFCD18839149 |