Venlafaxine

Modify Date: 2024-01-02 15:00:28

Venlafaxine Structure
Venlafaxine structure
 Common Name Venlafaxine
CAS Number 93413-69-5 Molecular Weight 277.402
Density 1.1±0.1 g/cm3 Boiling Point 397.6±27.0 °C at 760 mmHg
Molecular Formula C17H27NO2 Melting Point 72-74°C
MSDS N/A Flash Point 194.2±23.7 °C

 Use of Venlafaxine


Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.Target: SNRIVenlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. First introduced by Wyeth in 1993, now marketed by Pfizer, it is licensed for the treatment of major depressive disorder (MDD), as a treatment for generalized anxiety disorder, and comorbid indications in certain anxiety disorders with depression. In 2007, venlafaxine was the sixth most commonly prescribed antidepressant on the U.S. retail market, with 17.2 million prescriptions.Venlafaxine is a bicyclic antidepressant, and usually categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI), but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It works by blocking the transporter "reuptake" proteins for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are serotonin and norepinephrine. Additionally, in high doses it weakly inhibits the reuptake of dopamine, with recent evidence showing that the norepinephrine transporter also transports some dopamine as well, since dopamine is inactivated by norepinephrine reuptake in the frontal cortex. The frontal cortex largely lacks dopamine transporters; therefore, venlafaxine can increase dopamine neurotransmission in this part of the brain. Venlafaxine interacts with opioid receptors (mu-, kappa1- kappa3- and delta-opioid receptor subtypes) as well as the alpha2-adrenergic receptor, and was shown to increase pain threshold in mice. When mice were tested with a hotplate analgesia meter (to measure pain), both venlafaxine and mirtazapine induced a dose-dependent, naloxone-reversible antinociceptive effect following intraperitoneal injection. These findings suggest venlafaxine's seemingly superior efficacy in severe depression as narcotics become increasingly used as a measure of last resort for refractory cases.

 Names

Name venlafaxine
Synonym More Synonyms

 Venlafaxine Biological Activity

Description Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.Target: SNRIVenlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. First introduced by Wyeth in 1993, now marketed by Pfizer, it is licensed for the treatment of major depressive disorder (MDD), as a treatment for generalized anxiety disorder, and comorbid indications in certain anxiety disorders with depression. In 2007, venlafaxine was the sixth most commonly prescribed antidepressant on the U.S. retail market, with 17.2 million prescriptions.Venlafaxine is a bicyclic antidepressant, and usually categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI), but it has been referred to as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It works by blocking the transporter "reuptake" proteins for key neurotransmitters affecting mood, thereby leaving more active neurotransmitters in the synapse. The neurotransmitters affected are serotonin and norepinephrine. Additionally, in high doses it weakly inhibits the reuptake of dopamine, with recent evidence showing that the norepinephrine transporter also transports some dopamine as well, since dopamine is inactivated by norepinephrine reuptake in the frontal cortex. The frontal cortex largely lacks dopamine transporters; therefore, venlafaxine can increase dopamine neurotransmission in this part of the brain. Venlafaxine interacts with opioid receptors (mu-, kappa1- kappa3- and delta-opioid receptor subtypes) as well as the alpha2-adrenergic receptor, and was shown to increase pain threshold in mice. When mice were tested with a hotplate analgesia meter (to measure pain), both venlafaxine and mirtazapine induced a dose-dependent, naloxone-reversible antinociceptive effect following intraperitoneal injection. These findings suggest venlafaxine's seemingly superior efficacy in severe depression as narcotics become increasingly used as a measure of last resort for refractory cases.
Related Catalog
References

[1]. Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

[2]. Goeringer KE, et al. Postmortem tissue concentrations of venlafaxine. Forensic Sci Int. 2001 Sep 15;121(1-2):70-5.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 397.6±27.0 °C at 760 mmHg
Melting Point 72-74°C
Molecular Formula C17H27NO2
Molecular Weight 277.402
Flash Point 194.2±23.7 °C
Exact Mass 277.204193
PSA 32.70000
LogP 2.91
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.544
Storage condition Refrigerator, Under Inert Atmosphere

 Safety Information

Hazard Codes Xn
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin . R20/22:Harmful by inhalation and if swallowed .
Safety Phrases S37/39-S26
HS Code 2922509090

 Synthetic Route

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Efectin
N,N-Dimethyl-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethylamine
Cyclohexanol, 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-
1-(2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol
(±)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol
DL-Venlafaxine
MFCD03658865
Trevilor
Venlafaxine
(±)-1-[α-[(Dimethylamino)methyl]-p-methoxybenzyl]cyclohexanol
1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol
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Chemsrc provides Venlafaxine(CAS#:93413-69-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Venlafaxine are included as well.>> amp version: Venlafaxine

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