POT-4

Modify Date: 2024-01-10 19:26:37

POT-4 Structure
POT-4 structure
Common Name POT-4
CAS Number 934461-40-2 Molecular Weight 1627.85
Density N/A Boiling Point N/A
Molecular Formula C72H102N22O18S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of POT-4


POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 can be used for age-related macular degeneration research[1][2]

 Names

Name POT-4

 POT-4 Biological Activity

Description POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 can be used for age-related macular degeneration research[1][2]
Related Catalog
In Vitro A derivative of compstatin, a potent C3 inhibitor, POT-4 is a cyclic peptide that exhibits binding activity to C3, preventing cleavage to its active fragments C3a and C3b[2].
References

[1]. S. Kaushal, et al. Complement C3 inhibitor POT-4: Clinical Safety of Intravitreal Administration. ARVO Annual Meeting Abstract, 2009 Apr.

[2]. Robyn Troutbeck, et al. Therapeutic targeting of the complement system in age-related macular degeneration: a review. Clin Exp Ophthalmol. Jan-Feb 2012;40(1):18-26.

 Chemical & Physical Properties

Molecular Formula C72H102N22O18S2
Molecular Weight 1627.85
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