Neogambogic acid

Modify Date: 2024-01-05 09:39:17

Neogambogic acid Structure
Neogambogic acid structure
Common Name Neogambogic acid
CAS Number 93772-31-7 Molecular Weight 646.766
Density 1.3±0.1 g/cm3 Boiling Point 810.3±65.0 °C at 760 mmHg
Molecular Formula C38H46O9 Melting Point N/A
MSDS N/A Flash Point 250.2±27.8 °C

 Use of Neogambogic acid


Neogambogic acid, an active ingredient in garcinia, induces apoptosis and has anticancer effect. Neogambogic acid has significant inhibitory activity toward methicillin-resistant Staphylococcus aureus (MRSA)[1][2].

 Names

Name Neo-gambogic acid
Synonym More Synonyms

 Neogambogic acid Biological Activity

Description Neogambogic acid, an active ingredient in garcinia, induces apoptosis and has anticancer effect. Neogambogic acid has significant inhibitory activity toward methicillin-resistant Staphylococcus aureus (MRSA)[1][2].
Related Catalog
In Vitro Neogambogic acid inhibits HCT-8, Bel-7402, BGC-823, A549, and A2780 cell proliferation, with an IC50 between 1.75 and 3 μM. Neogambogic acid induces A549 cells apoptosis arrested the cells to G0/G1 phase in vitro[1].
In Vivo Neogambogic acid arrests A549-induced tumor growth in nude mice[1].
References

[1]. Wang K, et al. The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells.Acta Biochim Biophys Sin (Shanghai). 2011 Sep;43(9):698-702.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 810.3±65.0 °C at 760 mmHg
Molecular Formula C38H46O9
Molecular Weight 646.766
Flash Point 250.2±27.8 °C
Exact Mass 646.314209
PSA 139.59000
LogP 8.19
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.627

 Synonyms

2-Butenoic acid,4-(3a,4,5,7,10,11-hexahydro-8,9-dihydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,9H-furo(3,4-g)pyrano(3,2-b)xanthen-1-yl)-2-methyl
neogambogic acid
2-Butenoic acid, 4-[3a,4,5,7,10,11-hexahydro-8,9-dihydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,9H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-methyl-, (2E)-
V1982
(2E)-4-[10,12-Dihydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.0.0.0.0]docosa-4(13),5,11,15-tetraen-19 
-yl]-2-methyl-2-butenoic acid
2-Butenoic acid, 4-(3a,4,5,7,10,11-hexahydro-8,9-dihydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,9H-furo(3,4-g)pyrano(3,2-b)xanthen-1-yl)-2-methyl-
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