3-hydroxycoumarin

Modify Date: 2024-01-02 16:29:52

3-hydroxycoumarin structure	Common Name	3-hydroxycoumarin
	CAS Number	939-19-5	Molecular Weight	162.14200
	Density	1.446 g/cm3	Boiling Point	369.9ºC at 760 mmHg
	Molecular Formula	C₉H₆O₃	Melting Point	153-157 °C(lit.)
	MSDS	N/A	Flash Point	174.7ºC

Use of 3-hydroxycoumarin

3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage[1][2].

Name	3-hydroxycoumarin
Synonym	More Synonyms

Description	3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Alavi SJ, Sadeghian H, Seyedi SM, Salimi A, Eshghi H. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem Biol Drug Des. 2018;91(6):1125‐1132. [2]. Born SL, et al. Synthesis and reactivity of coumarin 3,4-epoxide. Drug Metab Dispos. 1997;25(11):1318‐1324. [3]. Asthana S, et al. Structure-Activity Relationship Study of Hydroxycoumarins and Mushroom Tyrosinase. J Agric Food Chem. 2015;63(32):7236‐7244.

Description

3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage[1][2].

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Alavi SJ, Sadeghian H, Seyedi SM, Salimi A, Eshghi H. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem Biol Drug Des. 2018;91(6):1125‐1132.

[2]. Born SL, et al. Synthesis and reactivity of coumarin 3,4-epoxide. Drug Metab Dispos. 1997;25(11):1318‐1324.

[3]. Asthana S, et al. Structure-Activity Relationship Study of Hydroxycoumarins and Mushroom Tyrosinase. J Agric Food Chem. 2015;63(32):7236‐7244.

Density	1.446 g/cm3
Boiling Point	369.9ºC at 760 mmHg
Melting Point	153-157 °C(lit.)
Molecular Formula	C₉H₆O₃
Molecular Weight	162.14200
Flash Point	174.7ºC
Exact Mass	162.03200
PSA	50.44000
LogP	1.49860
Index of Refraction	1.659

3-hydroxycoumarin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6797000

CHEMICAL NAME :: Coumarin, 3-hydroxy-

CAS REGISTRY NUMBER :: 939-19-5

BEILSTEIN REFERENCE NO. :: 0128032

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H6-O3

MOLECULAR WEIGHT :: 162.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 17,497,1967

Hazard Codes	Xn: Harmful;Xi: Irritant;
Risk Phrases	R22
Safety Phrases	S22-S24/25
WGK Germany	3
RTECS	GN6797000
HS Code	2932209090

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