6-(7-Nitro-benzo[2,1,3]oxadiazol-4-ylamino)-hexanoyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(7-dimethylaminocoumarin-4-yl)-NH2

Modify Date: 2024-01-11 17:01:09

6-(7-Nitro-benzo[2,1,3]oxadiazol-4-ylamino)-hexanoyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(7-dimethylaminocoumarin-4-yl)-NH2 Structure
6-(7-Nitro-benzo[2,1,3]oxadiazol-4-ylamino)-hexanoyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(7-dimethylaminocoumarin-4-yl)-NH2 structure
Common Name 6-(7-Nitro-benzo[2,1,3]oxadiazol-4-ylamino)-hexanoyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(7-dimethylaminocoumarin-4-yl)-NH2
CAS Number 945414-97-1 Molecular Weight 1598.847
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C78H111N21O16 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 6-(7-Nitro-benzo[2,1,3]oxadiazol-4-ylamino)-hexanoyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(7-dimethylaminocoumarin-4-yl)-NH2


NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2 is an substrate for hydrolysis of the matrix metalloproteinase stromelysin (MMP-3) and can be easily detected at Abs/Em=350/465 nm[1].

 Names

Name N2-{6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl}-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-leucyl-L-alanyl-L-norvalyl-L-tryptophyl-N6-{[7-(dimethylamino)-2-oxo-2H-chromen-4-yl]acetyl}-L-lysinamide
Synonym More Synonyms

  Biological Activity

Description NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2 is an substrate for hydrolysis of the matrix metalloproteinase stromelysin (MMP-3) and can be easily detected at Abs/Em=350/465 nm[1].
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Target

others

References

[1]. D M Bickett, et al. A high throughput fluorogenic substrate for stromelysin (MMP-3).Ann N Y Acad Sci. 1994 Sep 6:732:351-5.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C78H111N21O16
Molecular Weight 1598.847
Exact Mass 1597.851807
LogP 3.74
Index of Refraction 1.676

 Synonyms

L-Histidinamide, N-[(phenylmethoxy)carbonyl]-L-arginyl-L-arginyl-L-prolyl-L-phenylalanyl-N-[(1S,2S,6S,9S,12S)-2-hydroxy-9-(1H-imidazol-4-ylmethyl)-12-(methoxycarbonyl)-20,20-dimethyl-6-[(1S)-1-meth ylpropyl]-1-(2-methylpropyl)-4,7,10,18-tetraoxo-19-oxa-5,8,11,17-tetraazaheneicos-1-yl]-
N-[(Benzyloxy)carbonyl]-L-arginyl-L-arginyl-L-prolyl-L-phenylalanyl-N-[(10S,13S,16S,20S,21S)-16-[(2S)-2-butanyl]-20-hydroxy-13-(1H-imidazol-4-ylmethyl)-10-(methoxycarbonyl)-2,2,23-trimethyl-4,12,15 ,18-tetraoxo-3-oxa-5,11,14,17-tetraazatetracosan-21-yl]-L-histidinamide
MFCD00133577
6-(7-Nitro-benzo[2,1,3]oxadiazol-4-ylamino)-hexanoyl-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys(7-dimethylaminocoumarin-4-yl)-NH2