(+)-Biotin-PEG2-azide

Modify Date: 2024-01-02 18:47:25

(+)-Biotin-PEG2-azide Structure
(+)-Biotin-PEG2-azide structure
Common Name (+)-Biotin-PEG2-azide
CAS Number 945633-30-7 Molecular Weight 400.49600
Density N/A Boiling Point N/A
Molecular Formula C16H28N6O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (+)-Biotin-PEG2-azide


Biotin-PEG2-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[2-[2-(2-azidoethoxy)ethoxy]ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)
Synonym More Synonyms

 (+)-Biotin-PEG2-azide Biological Activity

Description Biotin-PEG2-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C16H28N6O4S
Molecular Weight 400.49600
Exact Mass 400.18900
PSA 163.74000
LogP 1.67316
Storage condition -20°C

 Synonyms

(+)-Biotin-PEG3-CH2CH2N3
(+)-Biotin-PEG3-azide
(+)-Biotin-PEG3-CH2CH2azide
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