Cyclohexanamine,N-cyclohexyl-N-nitroso-

Modify Date: 2024-01-14 17:55:27

Cyclohexanamine,N-cyclohexyl-N-nitroso- Structure
Cyclohexanamine,N-cyclohexyl-N-nitroso- structure
Common Name Cyclohexanamine,N-cyclohexyl-N-nitroso-
CAS Number 947-92-2 Molecular Weight 210.31600
Density 1.15g/cm3 Boiling Point 352.9ºC at 760mmHg
Molecular Formula C12H22N2O Melting Point 95-97ºC
MSDS N/A Flash Point 167.3ºC

 Use of Cyclohexanamine,N-cyclohexyl-N-nitroso-


N-Nitrosodicyclohexylamine (NDCHA) is a N-nitrosocompound with anti-androgenic activities. N-Nitrosodicyclohexylamine shows the competitive binding to androgen receptor (AR) against 5α-dihydrotestosterone and decreased the level of AR protein[1].

 Names

Name N,N-dicyclohexylnitrous amide
Synonym More Synonyms

 Cyclohexanamine,N-cyclohexyl-N-nitroso- Biological Activity

Description N-Nitrosodicyclohexylamine (NDCHA) is a N-nitrosocompound with anti-androgenic activities. N-Nitrosodicyclohexylamine shows the competitive binding to androgen receptor (AR) against 5α-dihydrotestosterone and decreased the level of AR protein[1].
Related Catalog
References

[1]. Hari, Sayaka, et al. (2006). Anti-Androgenic Activity of N-Nitrosodibenzylamine, N-Nitrosodiphenylamine and N-Nitrosodicyclohexylamine. JOURNAL OF HEALTH SCIENCE, 52(5), 522-531.

 Chemical & Physical Properties

Density 1.15g/cm3
Boiling Point 352.9ºC at 760mmHg
Melting Point 95-97ºC
Molecular Formula C12H22N2O
Molecular Weight 210.31600
Flash Point 167.3ºC
Exact Mass 210.17300
PSA 32.67000
LogP 3.63520
Index of Refraction 1.582
Storage condition -20℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HY4300000
CHEMICAL NAME :
Dicyclohexylamine, N-nitroso-
CAS REGISTRY NUMBER :
947-92-2
BEILSTEIN REFERENCE NO. :
1842001
LAST UPDATED :
199710
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H22-N2-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 69,103,1967

 Synthetic Route

 Synonyms

N-dicyclohexylnitrosamine
N-cyclohexyl-N-nitrosocyclohexanamine
DICYCLOHEXYLAMINE,N-NITROSO
N-Nitrosodicyclohexylamin
Dicyclohexylnitrosamine
Dicyclohexyl-nitroso-amin
dicyclohexyl-nitroso-amine
Cyclohexanamine,N-cyclohexyl-N-nitroso
Dicyclohexylnitrosamin
N-Nitrosodicyclohexylamine
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