(S)-(-)-Carvedilol
Modify Date: 2024-01-03 14:26:16
(S)-(-)-Carvedilol structure
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Common Name | (S)-(-)-Carvedilol | ||
|---|---|---|---|---|
| CAS Number | 95094-00-1 | Molecular Weight | 406.47400 | |
| Density | 1.25 g/cm3 | Boiling Point | 655.2ºC at 760 mmHg | |
| Molecular Formula | C24H26N2O4 | Melting Point | 114-115ºC | |
| MSDS | N/A | Flash Point | 350.1ºC | |
Use of (S)-(-)-Carvedilol(S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1]. |
| Name | (2S)-1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol |
|---|---|
| Synonym | More Synonyms |
| Description | (S)-Carvedilol, the S-enantiomer of Carvedilol, is a non-selective β/α-1 blocker. (S)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX)[1]. |
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| Related Catalog | |
| Target |
β/α-1 adrenergic receptor[1] |
| In Vitro | The β-receptor blocking activity of (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol, whereas both enantiomers show equipotent potency as α-blockers[1]. (S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro[1]. (S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs[1]. |
| References |
| Density | 1.25 g/cm3 |
|---|---|
| Boiling Point | 655.2ºC at 760 mmHg |
| Melting Point | 114-115ºC |
| Molecular Formula | C24H26N2O4 |
| Molecular Weight | 406.47400 |
| Flash Point | 350.1ºC |
| Exact Mass | 406.18900 |
| PSA | 75.74000 |
| LogP | 4.12890 |
| Storage condition | 2-8°C |
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(S)-(-)-Carvedilol CAS#:95094-00-1 |
| Literature: WO2007/97504 A1, ; Page/Page column 24-27 ; |
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(S)-(-)-Carvedilol CAS#:95094-00-1 |
| Literature: Crystal Growth and Design, , vol. 10, # 6 p. 2713 - 2733 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| UNII-0K47UL67F2 component OGHNVEJMJSYVRP-KRWDZBQOSA-N |
| (S)-(-)-Carvedilol |
| Carvedilol Impurity 11 |