ASP-4058 hydrochloride
Modify Date: 2024-01-09 18:07:59
ASP-4058 hydrochloride structure
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Common Name | ASP-4058 hydrochloride | ||
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| CAS Number | 952510-14-4 | Molecular Weight | 478.78 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H13ClF6N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ASP-4058 hydrochlorideASP-4058 hydrochloride is a next-generation, selective and orally active agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile[1]. |
| Name | ASP-4058 HYDROCHLORIDE |
|---|---|
| Synonym | More Synonyms |
| Description | ASP-4058 hydrochloride is a next-generation, selective and orally active agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile[1]. |
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| Related Catalog | |
| In Vivo | ASP4058 (p.o., daily for 21 days) hydrochloride reduces the clinical score in a dose-dependent manner and the cumulative clinical score from day 0 to 21 dpi at 0.03, 0.1 and 0.3 mg/kg are 15.5±1.48, 9.50±2.17 and 1.17±1.17, respectively, while that of vehicle-treated group is 15.5±0.619 in rats. ASP4058 prevents decreases in body weight of EAE rats[1]. ASP4058 (p.o., daily for day 12 to day 45) hydrochloride maintains the clinical score at a relatively low level and the cumulative clinical scores (18-45 dpi) among the groups treated with 0.1 and 0.3 mg/kg dosages are 6.90±2.85 and 5.60±2.21, respectively in mice. The ED50 values for ASP4058 is 0.063 mg/kg[1]. |
| References |
| Molecular Formula | C19H13ClF6N4O2 |
|---|---|
| Molecular Weight | 478.78 |
| Exact Mass | 478.063110 |
| 1H-Benzimidazole, 5-[5-[3-(trifluoromethyl)-4-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl]-1,2,4-oxadiazol-3-yl]-, hydrochloride (1:1) |
| 5-{5-[3-(Trifluoromethyl)-4-{[(2S)-1,1,1-trifluoro-2-propanyl]oxy}phenyl]-1,2,4-oxadiazol-3-yl}-1H-benzimidazole hydrochloride (1:1) |
| ASP-4058 HYDROCHLORIDE |