TPNA10168

Modify Date: 2024-03-01 18:38:47

TPNA10168 Structure
TPNA10168 structure
Common Name TPNA10168
CAS Number 957942-34-6 Molecular Weight 248.75
Density 1.54±0.1 g/cm3 (20 °C, 760 mmHg) Boiling Point 490.3±45.0 °C (760 mmHg)
Molecular Formula C9H9ClO2S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TPNA10168


TPNA10168 is an Nrf-2 activator that activates the Keap1-Nrf2-ARE pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases[1].

 Names

Name Benzo[c]thiophen-4(5H)-one, 1-chloro-6,7-dihydro-3-(methylsulfinyl)
Synonym More Synonyms

 TPNA10168 Biological Activity

Description TPNA10168 is an Nrf-2 activator that activates the Keap1-Nrf2-ARE pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases[1].
Related Catalog
References

[1]. Izumi Y, et al. TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway. J Pharmacol Sci. 2022 May;149(1):1-10.  

 Chemical & Physical Properties

Density 1.54±0.1 g/cm3 (20 °C, 760 mmHg)
Boiling Point 490.3±45.0 °C (760 mmHg)
Molecular Formula C9H9ClO2S2
Molecular Weight 248.75
Exact Mass 247.97300
PSA 81.59000
LogP 3.52360

 Synonyms

1-chloro-3-(methylsulfinyl)-4,5,6,7-tetrahydrobenzo[c]thiophen-4-one
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