DPA-714

Modify Date: 2024-01-06 11:56:00

DPA-714 Structure
DPA-714 structure
Common Name DPA-714
CAS Number 958233-07-3 Molecular Weight 398.474
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C22H27FN4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DPA-714


DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. [18F]DPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model[1][2].

 Names

Name DPA-714
Synonym More Synonyms

 DPA-714 Biological Activity

Description DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM), which is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. [18F]DPA-714 successfully evaluates for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model[1][2].
Related Catalog
Target

Ki: 7 nM (TSPO)[1]

References

[1]. James ML, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008 May;49(5):814-22.

[2]. Harhausen D, et al. Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke. PLoS One. 2013 Aug 2;8(8):e69529.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Molecular Formula C22H27FN4O2
Molecular Weight 398.474
Exact Mass 398.211792
LogP 2.86
Index of Refraction 1.581

 Synonyms

Pyrazolo[1,5-a]pyrimidine-3-acetamide, N,N-diethyl-2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethyl-
DPA-714
N,N-Diethyl-2-{2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl}acetamide
Y1H4D2VKZD
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