2-Aminothiazole

Modify Date: 2024-01-01 23:49:32

2-Aminothiazole Structure
2-Aminothiazole structure
 Common Name 2-Aminothiazole
CAS Number 96-50-4 Molecular Weight 100.142
Density 1.3±0.1 g/cm3 Boiling Point 216.4±9.0 °C at 760 mmHg
Molecular Formula C3H4N2S Melting Point 91-93 °C(lit.)
MSDS Chinese USA Flash Point 84.7±18.7 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 2-Aminothiazole


Aminothiazole (2-Aminothiazole) is a beginning point for synthesis of many compounds including sulfur drugs, biocides, fungicides, dyes and chemical reaction accelerators.IC50 value:Target:2-Aminothiazole can be used as a thyroid inhibitor in the treatment of hyperthyroidism and it has antibacterial activity. Also used as the acid tartrate. Recent studies using prion-infected neuroblastoma cell lines have suggested that aminothiazole may be used as a therapeutic drug for prion diseases.

 Names

Name 1,3-thiazol-2-amine
Synonym More Synonyms

 2-Aminothiazole Biological Activity

Description Aminothiazole (2-Aminothiazole) is a beginning point for synthesis of many compounds including sulfur drugs, biocides, fungicides, dyes and chemical reaction accelerators.IC50 value:Target:2-Aminothiazole can be used as a thyroid inhibitor in the treatment of hyperthyroidism and it has antibacterial activity. Also used as the acid tartrate. Recent studies using prion-infected neuroblastoma cell lines have suggested that aminothiazole may be used as a therapeutic drug for prion diseases.
Related Catalog
References

[1]. Gallardo-Godoy A, et al. 2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem. 2011 Feb 24;54(4):1010-21.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 216.4±9.0 °C at 760 mmHg
Melting Point 91-93 °C(lit.)
Molecular Formula C3H4N2S
Molecular Weight 100.142
Flash Point 84.7±18.7 °C
Exact Mass 100.009521
PSA 67.15000
LogP 0.38
Vapour Pressure 0.1±0.4 mmHg at 25°C
Index of Refraction 1.645
Water Solubility 100 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ2100000
CHEMICAL NAME :
Thiazole, 2-amino-
CAS REGISTRY NUMBER :
96-50-4
LAST UPDATED :
199806
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C3-H4-N2-S
MOLECULAR WEIGHT :
100.15
WISWESSER LINE NOTATION :
T5N CSJ BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
480 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
570 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4500 mg/kg/56D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal Liver - fatty liver degeneration Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200 mg/m3/7H/61D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Lungs, Thorax, or Respiration - dyspnea Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
200 mg/m3/7H/30D-I
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - chronic pulmonary edema Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
25 mg/m3/7H/62D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - fatty liver degeneration Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
557 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 155,17,1985

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22;R36/37
Safety Phrases S26-S36/37-S39
RIDADR 2811
WGK Germany 3
RTECS XJ2100000
Packaging Group I; II; III
HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2934100090
Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Articles34

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 Synonyms

thiazole-2-amine
EINECS 202-511-6
usafek-p-5501
2-amino-1,3-thiazole
Aminothiazole
1,3-Thiazol-2-amine
BASEDOL
2-Aminothiazole
ABADOLE
2-thiazolylamine
2-amino-thiazole
aminothiazol
RP 2921
2-Thiazolamine
THIAZYLAMINE
Abadol
MFCD00005325
thiazol-2-amine
cp1585
2-AMINO THIAZOLE
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